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Baylor Scott & White Heart and Vascular Hospital | Clinical Trials and Research
Soltero Cardiovascular Research Center : Operational excellence in cardiovascular research
Soltero Cardiovascular Research Center ( SCRC ) was founded in 1987 and is a part of the Baylor Scott & White Research Institute , and through Baylor Scott & White Heart and Vascular Institute , participated in more than 50 clinical trials and research studies during fiscal year 2024 . As a leader in the cardiovascular research field , SCRC is recognized as an innovative research center conducting highquality studies .
Cara East , MD , FAPCR , FACP , FACC - SCRC Director
Dr . Cara East serves as principal investigator in numerous studies while providing guidance and operational oversight to several principal investigators .
Widely published , Dr . East co-authored and contributed to several journal articles in fiscal year 2024 including :
• Koren M , East C , Rodriguez F , Stoekenbroek R , Zappe D , Toth PP , Robinson J . A randomized study to evaluate the effect of an “ inclisiran first ” implementation strategy vs usual care in patients with atherosclerotic cardiovascular disease and elevated low-density lipoprotein cholesterol : Rationale and design of the Victorion-Initiate Trial . Encore Poster , presented by A / Prof John Amerena . Cardiac Society of Australia and New Zealand .
• Wang X , East C , Pfeffer M , et . al . Sex differences in clinical characteristics and outcomes after acute myocardial infarction with low ejection fraction : Insights from PARADISE-MI . Journal of the American Heart Association . 2023 Sept 5 ; 12 ( 17 ) epub 223 August 23 .
• Kandzari DE , Townsend RR , Kario K , Mahfoud F , Weber MA , Schmieder RE , Pocock S , Tsioufis K , Konstantinidis D , Choi J , East C , Lauder L , Cohen DL , Kobayashi T , Schmid A , Lee DP , Ma A , Weil J , Agdirlioglu T , Schlaich MP , Shetty S , Devireddy CM , Lea J , Aoki J , Sharp ASP , Anderson R , Fahy M , DeBruin V , Brar S , Böhm M ; SPYRAL HTN-ON MED Investigators . Safety and Efficacy of Renal Denervation in Patients Taking Antihypertensive Medications . Journal American College of Cardiology . 2023 November 7 ; 82 ( 19 ): 1809-1823 .
• Koren MJ , Rodriguez F , East C , Toth PP , Watwe V , Abbas CA , Sarwat S , Kleeman K , Kumar B , Ali Y , Jaffrani N . An “ Inclisiran First ” Strategy vs Usual Care in Patients With Atherosclerotic Cardiovascular Disease . Journal American College of Cardiology . 2024 May 21 ; 83 ( 20 ): 1939-1952 . Epub 2024 April 7 .
SCRC led several key multi-year studies .
• SPYRAL ON MED - Global clinical study of renal denervation with the Symplicity Spryal multielectrode renal denervation system in patients with uncontrolled hypertension on standard medical therapy . Principal investigator : Cara East , MD .
• SPYRAL OFF MED - Global clinical study of renal denervation with the Symplicity Spyral multielectrode renal denervation system in patients with uncontrolled hypertension in the absence of antihypertensive medications : SPYRAL Study . The Dallas site ranked # 1 in enrollment and ranked # 3 for randomization . Principal investigator : Cara East , MD .
• SPYRAL DYSTAL - Global clinical study of renal denervation in the distal main and first order branch renal arteries using the Symplicity Spyral multi-electrode renal denervation system . Principal investigator : Cara East , MD .
While these studies closed in fiscal year 2024 , the SPYRAL AFFIRM continues as a global clinical study .
Additional SCRC studies in fiscal year 2024 include :
AFFIRM - The Spyral AFFIRM is a global clinical study of renal denervation with the Symplicity Spyral Renal Denervation System in subjects with uncontrolled hypertension . Principal investigator : Robert Stoler , MD .
AMGEN Lp ( a ) - A multi-center , cross-sectional study to characterize the distribution of lipoprotein ( a ) levels among patients with documented history of atherosclerotic cardiovascular disease ( ASCVD ). Principal investigator : Cara East , MD .
BOLT - A prospective , multi-center study of patients with deep vein thrombosis to evaluate the safety and efficacy of the Indigo Aspiration System . Principal investigator : Javier Vasquez , MD .