CN bond formation reactions catalyzed by Co pincer complexes
Adil Les
Department of Chemistry, School of Science and Humanities,
Nazarbayev University, Nur-Sultan, Kazakhstan
Email: [email protected]
Abstract
CN bond formation plays an important role in synthetic chemistry because crucial classes of compounds,
such as amines and amides, can be formed as a product of a reaction. Amines and amides are widely used
and ubiquitous in the natural products field, pharmaceuticals, agrochemicals, dye industry, materials
science, etc. CN bond formation reactions were actively developed by the catalysis of the noble transition
metals such as palladium, ruthenium, and iridium. Nevertheless, in recent times Co-derived pincer
complexes attract more attention in catalytic applications as a cheap and earth-abundant alternative to the
expensive conventional noble metal catalysts. Co complexes with pincer ligands can show the efficiency
in reactions of CN bond formation due to the ability of pincer ligands to control the chemical properties of
metals through modification of ligand parameters. Alkylation of amines, formations of amides and C-N
coupling constitutes the familiar reaction of CN bond formation catalyzed by Co pincer complexes. The
most common reaction is alkylation of amines, which was investigated by Kempe’s, Kirchner’s,
Balaraman’s and Zhang’s groups. Unfortunately, there are not so many articles available about the reactions
of the formation of amides and C-N coupling catalyzed by Co pincer complexes which were studied only
by Milstein’s and Bala’s group, respectively. According to the mentioned research groups, the overall
reaction products were formed with decent results of conversion which show the good potential of the
application of Co pincer complexes in the catalysis of CN bond formation reactions.
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