Multicomponent approach for the synthesis of novel azulene derivatives
Gong Jing a , Sagadat Amandykova b , Aidana Gimnkhan b , Anatoly A. Peshkov b ,
Vsevolod A. Peshkov b , Olga P. Pereshivko b
a
College of Chemistry, Chemical Engineering and Materials Science,
Soochow University, Suzhou, 215123, P. R. China
b
Department of Chemistry, School of Sciences and Humanities,
Nazarbayev University, Nur-Sultan, Kazakhstan
E-mail: [email protected]
Abstract
Multicomponent reactions are becoming an attractive and easily accessible tool for the synthesis of complex
heterocycles. Pharmaceuticals and natural products contain a variety of heterocyclic moieties. Modern
methodologies have limitations such as usage of metal catalysts or large number of steps, resulting in a low
yield. The MCRs become the area of interest of many researchers due to its simplicity yet efficient outcome
in the synthesis of a complex molecule. In this article, arylglyoaxals, 1,3-cyclicdicarbonyls and azulene
were utilized in one-pot manner producing a novel azulene derivatives with a good yield in mild conditions.