Efficient, mild and chemoselective hydroboration of carbonyl compounds
using posphinite POCN pincer complexes of Nickel(II)
Assyl Adamov, Kristina Gudun, Medet Segizbayev, Andrey Khalimon*
Department of Chemistry, School of Science and Technology, Nazarbayev University,
Astana, Kazakhstan
Email: [email protected], [email protected]
Abstract
One of the efficient ways to synthesize important organic compounds from unsaturated organic
molecules is hydroboration reaction. In uncatalyzed hydroboration reaction boron inserts to the
least sterically congested and least substituted carbon atom, while catalyzed hydroboration
reaction allows to manipulate chemo-, regio- and stereoselectivity of the reaction. Catalytic
systems based on heavy late transition metals(Ir, Rh, etc.) have proved effective to catalyze
hydroboration of carbonyl compounds, but are limited by high cost and dearth. Otherwise,
chemistry of base transition metal (Ni, Fe, Co) have received interest due to their availability
and considerable catalytic activity. One of effective catalytic system for hydroboration of
carbonyl compounds are based on pincer complexes. Unique properties of pincer ligands such
as rigid nature, ability to easily change steric and electronic properties contributes to stability
and reactivity of pincer complexes allowing to control selectivity of catalytic reactions. In this
paper, we inform preparation our catalytic system and shows reactivity studies of novel Ni(II)
pincer complexes with iminophosphinite POCN ligands. In more detail, efficient and mild
hydoboration of unsaturated organic molecule such as aldehydes, ketones, esters and amides
based on novel metal catalyst will be reported.
This work was supported by Nazarbayev University through NU Research University
Development Program (grant to AYK # 2016023)
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