impact on biomarkers and metabolic factors in adolescent girls .
Yoost , an associate professor of obstetrics and gynecology at the Joan C . Edwards School of Medicine and the only fellowship-trained pediatric and adolescent gynecologist in West Virginia , has teamed with Holly Cyphert , PhD , associate professor of biological sciences in Marshall ’ s College of Science , to determine how maternal PCOS may influence the metabolic health of young girls during puberty .
Yoost emphasized the challenges of diagnosing PCOS during adolescence , citing the complexity of hormonal and metabolic changes . “ While acknowledging a potential hereditary connection in some families , the exact onset of PCOS remains unclear ,” Yoost said . “ Through this study , we aim to assess young girls with a first-degree family history of PCOS in order to help guide future diagnoses and monitoring of this at-risk population .”
Funded by a grant from the West Virginia Clinical and Translational Science Institute , this prospective study seeks to compare and analyze androgens , ovarian function markers , metabolic factors such as insulin and lipid levels , and specific bile acids as biomarkers among adolescents before their first menstrual period . If present , the biomarkers may indicate risk of disease . The study will involve evaluation of females ages 8 to 13 , including their medical history , timing of pubertal changes , and laboratory tests . Participants will be compensated for their involvement in the study .
“ There is an interplay between PCOS , insulin resistance , and familial inheritance patterns ,” Cyphert said . “ This study is innovative in that it involves assessment of bile acids as biomarkers for disease . Dr . Yoost and I previously published that bile acids are elevated among older adolescent PCOS patients . We hope to demonstrate that bile acids may also serve as biomarkers in early puberty .”
The findings from this study have the potential to inform early detection and intervention strategies for PCOS , ultimately improving the long-term health outcomes of affected individuals .
Marshall is now accepting patients for this study . To refer a patient , please contact Research Coordinator Morgan Ruley at 304-691-1458 or obgynresearch @ marshall . edu .
West Virginia Medical Journal • June 2024 • 13