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EVENT FORMAT
Keynote
2020
Januar y
12-2 3
Supramolecular Chemistry and the Design of Anti-infectives
DESCRIPTION
Supramolecular chemistry has led to a remarkable array of compounds having novel properties. In addition, many
new materials have emerged from studies in this area. Although a number of biological properties have been mani-
fested by supramolecular compounds, this remains an understudied area. Our efforts to develop synthetic ion trans-
porters resulted in compounds that show a range of biological activities. In particular, the synthetic ion channels that
we call hydrophilic show anti-bacterial activity, but they also show considerable activity as adjuvants that enhance
the potency of antibiotics and even reverse resistance of some organisms to those drugs. Three structurally different
classes of compounds have been designed, prepared, and studied that show potential as antimicrobials.
SPEAKER George Gokel
Distinguished Professor of Science Chemistry and Biochemistry and Associate
Director of the Center for NanoScience at the University of Missouri-St. Louis