Volume 68, Issue 2 Louisville Medicine | Page 14

GETTING TO THE HEART OF MEDICINE HEART AND SOUL AUTHOR Christopher Fine, MD “My mother had it, too,” she had told me in the past, “but she fought to the very end. I plan on doing the same.” Her hands were petite and cracked with decades of hard work that one could only acquire from a family farm. She had the kind of hands that longed to be touched, frequently pulling you in for an embrace at your every meeting, when a hug was not yet taboo from the pandemic. She sat in the same infusion chair every session. It had a light blue color that glowed in the late morning sun. Her head scarf changed every time I saw her, which wasn’t a coincidence: an inside joke for all her fellow patients. That loud personality–which always brought to mind the joy of blowing bubbles across the top of a milkshake–was what made her “her.” These are the human elements that can get lost in modern medicine, but that make all the difference. The melding of cardiology and oncology disciplines, albeit in its infancy as far as recognized subspecialties goes, has an incredible opportunity to treat the whole patient again. The totality of treatment can encompass physical, mental, emotional and spiritual health across multiple fields. But I’ve always asked myself, what is my best role as her cardiologist? How can I treat her to the best of my ability? In order to do no harm, a portion of the Hippocratic oath we all take in medical school, we analyze risk/benefit ratios. This ratio is frequently in the form of the number needed to treat (NNT). This metric is used typically in studies about prevention, for instance, of death or major adverse cardiac event. Consider a patient having a myocardial infarction. On top of primary revascularization, which is by far the most impactful treatment we can provide, we are quick to prescribe high-intensity statins and aspirin as essential medications for guideline-directed medical therapy. Similarly, for heart failure patients with a reduced left ventricular ejection fraction, we prescribe even more medications. In some situations, we recommend implantable devices to improve the synchrony of ventricular contraction, with the goal to make the patient live longer and feel better. Depending on the trial you draw information from, the NNT for statins (in patients with and without a prior heart attack) 12 LOUISVILLE MEDICINE