Veterinary Toxicology Basic and Clinical Principles - Tabla de Contenido

xxvi Contents
Penicillium-associated tremorgenic mycotoxins Aspergillus-associated tremorgenic mycotoxins Neotyphodium-associated tremorgenic mycotoxins Claviceps-associated tremorgenic mycotoxins Bermudagrass staggers Toxicokinetics Mechanism of action Toxicodynamics Central effects Peripheral effects Genotoxicity Acute toxicity Potential interactions Clinical aspects of tremorgenic mycotoxicoses Diagnosis Treatment Prevention Concluding remarks and future directions References	1074 1075 1076 1076 1076 1076 1077 1077 1077 1078 1078 1078 1078 1079 1079 1079 1079 1080 1080	Concluding remarks and future directions References Section O Feed and water contaminants 76. Melamine and cyanuric acid Karyn Bischoff Introduction Source Pharmacokinetics / toxicokinetics Mechanism of action Toxicity Clinical signs Clinical pathology Pathology Diagnosis Treatment and prognosis Concluding remarks and future directions References	1101 1101 1109 1110 1110 1111 1111 1112 1112 1112 1113 1113 1113
74. Trichothecenes		77. ionophores
Rhian B. Cope		Ramesh C. Gupta, HuiChang Chae, Kirsten B. Ezell, and Robin B. Doss

Introduction	1083
General toxicological characteristics	1083
T-2 toxin	1086
Deoxynivalenol( DON, vomitoxin)	1088
Stachybotryotoxicosis, myrotheciotoxicosis
and dendrodochiotoxicosis	1090
Concluding remarks and future
directions	1090
References	1090

75. Zearalenone

Ramesh C. Gupta, Michelle S. Mostrom, and Timothy J. Evans

Introduction	1095
Background	1095
Toxicokinetics	1096
Mechanism of action	1097
Toxicity	1098
Swine	1099
Ruminants	1099
Equine	1100
Poultry	1100
Treatment	1100

Biomonitoring and risk assessment 1100

Introduction Background

Pharmacology and pharmacokinetics Pharmacology Pharmacokinetics

Mechanism of action Toxicity

Pathogenesis Occurrence Clinical signs Postmortem findings Histopathologic findings other laboratory findings Diagnosis and differential diagnosis Treatment Concluding remarks and future directions Acknowledgments References

78. Non-protein nitrogen( urea) and hypermmonemia

Rhian B. Cope

Introduction and background Chemistry

1117 1117 1119 1119 1120 1121 1123 1123 1123 1126 1127 1127 1129 1130 1132

1133 1133 1133

1137 1137

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