xxiv Contents
Susceptibility to toxicity |
976 |
Mechanism of action |
976 |
Toxicity |
981 |
Undesirable effects of cottonseed meals on |
eggs |
982 |
Diagnostics |
984 |
Differential diagnosis |
984 |
Prevention |
984 |
Concluding remarks and future |
directions |
985 |
References |
985 |
67. Phytoestrogens
Timothy J. Evans
Introduction |
987 |
Description |
987 |
Historical background |
989 |
Pharmacokinectics / toxicokinetics |
989 |
Plant impact |
989 |
Animal biotransformation |
990 |
Absorption |
991 |
Tissue distribution |
992 |
Excretion |
993 |
Mechanisms of action |
994 |
Estrogen receptors |
994 |
Impact on steroidogenesis |
995 |
Additional impact on cell functions |
996 |
Altered signal transduction and cell |
proliferation |
997 |
Antioxidant activity |
997 |
Potential for nonlinear dose-response |
curves |
997 |
Adverse effects on reproduction |
997 |
Developmental effects |
997 |
Hormones and estrous cycles |
998 |
Female subfertility |
999 |
Male subfertility |
1000 |
Risk assessment |
1001 |
Livestock production |
1001 |
Laboratory studies |
1001 |
Diagnosis and treatment of phytoestrogen exposure |
in livestock |
1001 |
Concluding remarks and future |
directions |
1002 |
References |
1002 |
Section N Mycotoxins
68. Aflatoxins
Robert W. Coppock and Ralph C. Christian Chapter description 1009
Introduction Historical identification of aflatoxins Public health and economics of aflatoxin contamination Government regulations Aflatoxigenic fungi Environments for aflatoxin production
Production of aflatoxins under field and storage conditions Moisture and temperature management of stored commodities In vivo production of aflatoxins Aflatoxins in feedstuffs and foods Sources and occurrences of aflatoxicosis Chemistry, sampling and analysis
Toxicokinetics, biotransformation Absorption Biotransformation and translocation to edible animal products Varying species sensitivity to AFs Translocation to milk Toxicodynamics Immunotoxic effects Reproductive and teratogenic effects
Toxicopathology of aflatoxins Clinicopathology
Macroscopic and microscopic pathology Edema and hemorrhage Hepatic lesions other lesions Differential diagnosis Preventative, antidotes and treatment
Reduction of toxicity in commodities, feedstuffs and foodstuffs
Treatment Aflatoxin interactions Concluding remarks and future directions References
69. Ergotism and fescue toxicoses
Timothy J. Evans, Eric Bailey, and Ramesh C. Gupta
Introduction Introductory remarks on ergot, ergot alkaloids, and ergotism Ergopeptine alkaloid contamination of feedstuffs and regulatory and public health concerns
Ergotism and fescue toxicosis Background Information about ergot infection of grains and grasses
1009 1009
1010 1010 1010 1011
1011
1012 1012 1012
1012 1013 1014 1014
1014 1014 1015 1017 1017 1017 1018 1018
1018 1018 1019 1019 1019 1019
1019 1020 1020
1020 1021
1025
1025
1026 1026
1026