GASTROENTEROLOGY
Wheaten Terrier’s, Irish Setters, with their individual
nuances.
Monitoring Response to Therapy
Follow up endoscopy and histopathology:
Although repeated IBD activity index scores are the
most common way patients are monitored repeat
endoscopic and histopathology studies have been
regularly performed in academic/research studies.
Improving IBD index scores is usually associated
with an improved intestinal mucosal appearance
endoscopically and improved intestinal mucosal
integrity and, if specialised organism detecting
techniques are used, with a decrease in mucosal
adhesion and invasion of potential pathogens; but
the actual lamina propria inflammatory cell numbers may not be decreased in these repeat biopsies.
One explanation for this may be decreased post
event apoptosis of the resident lymphocyte populations another may be continued unresolved underlying perturbations.
Selected references in text
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Sauter, S.N. et al (2006) Effects of probiotic bacteria in dogs
with food responsive diarrhoea treated with an elimination
diet. J Anim Physiol Anim Nutr 90:269–277
German, A.J., et al (2010) First-choice therapy for dogs presenting with diarrhoea in clinical practice. Vet Rec 21:810
Herstad, H.K. et al (2010) Effects of a probiotic intervention
in acute canine gastroenteritis--a controlled clinical trial. J
Small Anim Pract 51:34
Bybee, et al (2011) Effect of the probiotic Enterococcus
faecium SF68 on presence of diarrhea in cats and dogs
housed in an animal shelter. J Vet Intern Med 25:856
Dossin, O. et al (2011) Effect of Parvoviral Enteritis on Plasma Citrulline Concentration in Dogs. J Vet Intern Med 25:
215–221
Rath, H.C. (2003) The role of endogenous bacterial flora:
bystander or the necessary prerequisite? Eur J Gastroenterol Hepatol 15:615–620
Rossi, G. et al (2014) Comparison of Microbiological, Histological, and Immunomodulatory Parameters in Response
to Treatment with Either Combination Therapy with Prednisone and Metronidazole or Probiotic VSL#3 Strains in
Dogs with Idiopathic Inflammatory Bowel Disease. PLoS
ONE 9:e94699. doi:10.1371/journal.pone.0094699
Remainder of references available on www.vet360.
vetlink.co.za
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