Product Name : MILBEMAX ® Tablets for Cats |
Page No : |
3 of 4 |
Date of issue : |
November 2008 |
MATERIAL SAFETY DATA SHEET Section 10 - Stability and Reactivity
Chemical Stability : Product is stable under normal conditions . Section 11 - Toxicological Information
Acute Toxicity : |
Oral : |
Low toxicity . |
Oral toxicity for the finished product in rats is ; LD 50 > 200mg / kg |
Dermal : |
Low toxicity . |
Dermal toxicity for the finished product in rats is ; LD 50 > 200mg / kg |
Inhalation : |
Low toxicity . |
Tested inhalation toxicity in rats is LC 50 ( 4hr )> 5000mg / m 3 |
Local Effects : |
Irritation - ( Based on studies with Rabbits ) |
Skin : |
Non-irritant |
Eyes : |
Non-irritant |
Sensitisation - |
( Based on results on guinea-pigs ) |
Skin : Chronic Toxicity :
Ecological data for Milbemycin oxime |
Species |
LC 50 |
Common Carp ( 48 hrs ) |
0.059 ppm |
Daphnia ( 3hrs ) |
> 100 mg / L |
Non-sensitiser Milbemycin oxime In subchronic and chronic feeding studies in dogs , no compound-related signs of toxicity were observed at 1.5 mg / kg ( 5-times the monthly use level ). Mild , transient ataxia and / or trembling were observed in puppies dosed at 9 mg / kg and 15 mg / kg daily for three days . No adverse effects on reproduction or pup development occurred in dogs dosed at three times the recommended monthly dose level , given daily throughout pregnancy . In a 3-month oral gavage study with rats , no signs of toxicity were observed at 3 mg / kg / day ( equivalent to almost 200-times the recommended monthly dose for dogs ). Effects at 15 and 100 mg / kg / day , given daily for 3 months , included a decrease in extramedullary haematopoetic foci in the spleen at both dose levels , with mild anaemia and fatty changes in the liver occurring at the high dose only . Praziquantel Praziquantel was reported to be non-tumorigenic in non-standard lifetime carcinogenicity assays in hamsters and rats . There is no direct evidence that Praziquantel is carcinogenic , and no cause for concern based on decades of use in millions of humans .
Section 12 - Ecological Information
There is no ecological information available for Praziquantel
After intended use :
UN Number :
Section 13 - Disposal Considerations
Dispose of empty , used containers by wrapping in paper and putting in garbage .
Section 14 - Transport Information None allocated
Novartis Animal Health Australasia Pty Ltd