Vapouround magazine ISSUE 23 | Page 51

What does nicotine do to us when vaped? When someone takes nicotine into their body it will produce both stimulating and sedative effects. Nicotine changes the levels of chemicals such as dopamine and noradrenaline in the brain, altering mood and concentration, which many people find enjoyable and some experience a pleasurable nicotine rush. Studies suggest that increased levels of beta endorphin can help reduce anxiety, and feelings of alertness. In brief However, nicotine may also increase the heart rate, blood pressure and heart stroke pressure. Nicotine is a highly addictive substance. Nicotine can also cause a range of side effects such as, indigestion, circulatory effects, disturbed sleep, peptic ulcers, diarrhoea and heartburn among others. At this moment in time, nicotine is not classified as a cancer-causing compound but may cause possible DNA damage that ‘could’ increase the risk of cancer. The main issue is the method of nicotine delivery. In combustible cigarettes, where you have the burning of tobacco to inhale nicotine, smokers are also going to inhale upwards of 7,000 chemicals, of which at least 69 are known to cause cancer. Moving to less harmful alternatives such as vaping allows users a much safer method of getting that nicotine fix, which is where the now famous 95 percent less harmful Public Health England statistic comes in, as vaping has been shown to reduce exposure to harmful, cancer causing compounds significantly. Studies show it has some positive effects but also comes with side effects. Currently, it is not classified as a cancer-causing compound. The method of nicotine delivery is where the major health issues arise. Despite some misconceptions and stigma still surrounding e-cigarettes, vaping is significantly better for harm reduction than carrying on smoking. Dr Richard Cunningham has a PhD in medicinal chemistry from Queen’s University Belfast, where he also worked as a post doctoral researcher. Dr Cunningham has also worked as a research instructor at the University of South Alabama’s Mitchell Cancer Institute. Among his areas of expertise are organic synthesis, nucleosides, nucleotides, cellular biology, vitamins, aminoglycosides, drug delivery, phosphorous chemistry and chemical analysis. VM23 | 51