UAB Insight Orthopaedics Volume 1

K E Y N O T E P R E S E N TAT I O N S Non-Profit Org. U.S. Postage Thomas Hunt III, MD – Hand Mini-fragment Fixation Course, Pulvertaft Hand Centre, Derby, UK; April 26-27, 2012. John Gould, MD – Deformity Day Annual Conference, University of Heidelberg, Heidelberg, Baden-Württemberg, Germany; October 1, 2012. PAID Permit No. 1256 Birmingham, AL JNWB 412 • 500 22nd Street South 1530 3rd ave s birmingham al 35294-0104 VOL. 1 NO. 12 Orthopaedics INSIGHT Reed Estes, MD – “Dancing with the Surgeon: A brief look at the biomechanics of dance and injury prevention,” Alabama Dance Festival. Alabama School of Fine Arts, Birmingham, Alabama; January 28, 2012. T h e U ni v e r sit y o f A l a ba m a at Bi r m ingha m Published by the UAB Health System, 500 22nd Street South Birmingham, AL 35233 ©2012 by The Board of Trustees of The University of Alabama for the University of Alabama at Birmingham. Second class postage paid by UAB Bulk Mail Dept. Postmaster address changes to: In this comparison of mouse bones in culture dishes, UAB Insight, 500 22nd Street South regular media was added in the image at right and a new Suite 410, 1530 3rd Ave South angiogenic drug (HA-1) was added to the bottom image. Birmingham, AL 35294 Eight UAB Orthopaedics physicians named Best Doctors in America® Herrick J. Siegel, MD J. Scott Doyle, MD issue hi g h l i g hts Hypoxia, Angiogenesis, and Osteoinduction UAB Orthopaedics’ Response to 2011 Tornadoes John S. Gould, MD Hunt Edits Operative Techniques in Hand, Wrist, Rena L. Stewart, MD Richard D. Meyer, MD Steven M. Theiss, MD Thomas R. Hunt III, MD William P. Garth, MD and Forearm Surgery To refer a patient, call: 1-800-822-6478 2 UAB Helps AF Develop Trauma Teams Three New Physicians Join UAB Orthopaedics UAB Orthopaedics is deeply invested in multiple areas interested in whether the pathway also might be useful in 2 of basic research. One of the most promising areas is the bone repair. They found that increased blood vessel formation in Publications of Note 3 work of pediatric orthopaedist Shawn Gilbert, MD, who is investigating the role of the hypoxia inducible factor (HIF) genetically altered mice allowed healing with much more UAB Medicine News 3 pathway and angiogenesis in the skeleton using genetic and bone, whereas those with underdeveloped blood supply did pharmacologic interventions and also is seeking to identify not form bone well during healing. In looking for a way to Measures of Success visit UAB Medicine PHYSICIAN HQ: UABmedicine.org/physician UAB Response to 2011 Tornadoes Faculty Listing For more issues of UAB Insight and the latest news and updates, Hypoxia, Angiogenesis, and Osteoinduction 3 additional HIF activating proangiogenic compounds. induce blood vessel formation with drugs in normal mice, Keynote Presentations 4 organisms use to sense and respond to poor availability of already used in clinical practice for other conditions, oxygen and nutrients. Gilbert and his colleagues have been induced blood vessel formation and led to better bone The HIF pathway is the major mechanism many living he found desferrioxamine (DFO), an inexpensive molecule continued on page 2