Trustnet Magazine Issue 43 September 2018 | Page 22

Your portfolio “Many firms are now encountering a lot of competition as patents come to an end on some of their key products” The Biotech Growth Trust (580.40%) IT Biotechnology & Healthcare (466.51%) International Biotechnology Trust (434.02%) 600% Healthcare brushed off the threat, pointing out Amazon is focusing more on the supply of medicines rather than manufacturing. “There have always been economies of scale in procurement, particularly with generics, and these guys can have a lot of volume on the direct side,” he says. “Amazon is already active in over-the-counter pharmaceuticals via its Solimo range, which is manufactured by Perrigo. So there is nothing really new here, and while this incremental creep into healthcare is continuing, I think generally it is well appreciated by the healthcare investment community.” 500% 400% 300% 200% 100% 0% -100% due to a slowdown at the top: “The industry has matured quite a bit over the past five to 10 years. A lot of the big names now have quite significant market capitalisations, while over the course of that period innovation has been dramatic. Many firms are now encountering a lot of competition as patents come to an end on some of their key products,” he explains. According to Paul Mason, manager of BB Healthcare – one of the newest trusts in the sector – higher standards The threat from Amazon FE TRUSTNET PERFORMANCE OF TRUSTS VS SECTOR OVER 10YRS administration is so far fostering innovation in the sector with plans for speedier drug approvals, including the controversial “right to try” bill for terminally ill patients. Meanwhile, US health secretary Alex Azar has ruled out a key election proposal that threatened to see the government negotiate directly with drug companies for Medicare health plans – considered an existential threat to many healthcare companies. Even though investors have returned to the sector, however, growth has continued to lag, with valuations at many of the bigger firms still hovering well below 2015 highs. This, says Geoff Hsu, manager of The Biotech Growth Trust, is in part In January 2018 it was announced that Amazon would launch a healthcare company for the 1.2 million employees of Berkshire Hathaway and JP Morgan in the US and there are fears that the biotech sector could be the next industry to be disrupted by the online retail giant. However, Paul Mason of BB [ BIOTECHNOLOGY ] 24 / 25 Source: FE Analytics are also playing a role in the decline of large caps. “We live now in an age of evidence-based medicine,” he explains. “Twenty years ago Pfizer and Glaxo [Smith Kline] etcetera ruled the world because they could spend billions of dollars on marketing. Today, doctors have greater access to research and so it really is about how good the drug is.” This, he says, is leading to fierce competition from smaller firms, many based in China, that can now develop and launch better drugs faster than larger rivals. Specialise for success This shifting landscape is visible in the Biotech Growth trust. Long the sector leader, a failed trial at key holding Celgene (a $63bn company) followed by a general sell-off in large caps has hit the trust hard, with shares barely breaking even since July 2015. Hsu says the portfolio has been repositioned, but that it retains a “healthy weight” to large caps, which he believes will recover. trustnet.com