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Tramadol that have serotonergic and noradgenic systems. A research that has been conducted on mice has shown some validity in possibly using the drug for treating the symptoms of depression, however, the doctors do not believe that it can be used as an anti-depressant unless it is needed on such cases when the other depression meds that are given have failed. On such case, some doctors would recommend the pain relief medication Tramadol for depression. Tramadol releases serotonin, whereas it is dangerous to take Tramadol medication along with the other forms of depression meds. The combination of selective serotonin and non-serotonin reuptake inhibitors which are taken for depression along with Tramadol medication will only increase the serotonin toxicity in the person’s body and that could lead to fatal. According to the recent warning information which has been published in the PDR, that many of the physicians are well aware of these new researchers and they are aware of the danger that would cause to an individual when Tramadol is mixed with any other depression medication. However, most of the doctors would not prescribe Tramadol for depression to any patient as there are not enough researchers has been made to prove its effectiveness on humans that overcomes the given PDR warnings. There is a chance that the depression in person might get worsened just by using Tramadol due to its addictive nature and its withdrawal effects. Do consult with your doctor before taking Tramadol medication for treating your depression. Tramadol for Dogs Some of the veterinarians would recommend this drug for dogs to manage their pain. It is safe to give this medication to dogs only under the guidance of a veterinarian. Just like any other medication, Tramadol is used for treating both chronic and acute pain and it helps your dog to recover from surgery or it helps to manage the that are associated with osteoarthritis when it is taken along with many other medications.