The Specialist Forum Volume 13 No 11 November 2013

PAIN Studies confirm safety and efficacy of lornoxicam L ornoxicam is a relatively new nonsteriodal anti-inflammatory drug (NSAID). It belongs to the oxicam group and as with other NSAIDs, lornoxicam inhibits prostaglandin (PG) synthesis via inhibition of cyclooxygenase (COX), but does not inhibit 5-lipoxygenas. Lornoxicam inhibits polymorphonuclear (PMN)-leukocyte migration, inhibits the release of superoxide from human PMN-leukocytes, inhibits the release of platelet derived growth factor (PDGF) from human platelets and stimulates the synthesis of proteoglycans in cartilage in tissue culture. Lornoxicam was reported to be 100-fold more potent (on a molar basis) than tenoxicam in inhibiting D2 f ?X][?[??]?[[??X?X\??]X???]\?[??]???\?Y\?]?[?X?]?HY??X????H[???L??\?\\?[?X?\??][??[??X\?\?[???[??\?[??[?[??]Y[??[?]?[???[?[???[??[[?[?\?X?[?[?KZ[??[[X]?B?Y??X???]?[?[?\?X??[??H[?[?[X[Z[?[?[?^?YY?]?[??X?[H[?\??X?[H?H\??[X][HL?H[?L?Y???\?X?]?[N?\?X\?]\???\?H??^Y??[?H?[???\\?Y?[??Y]X?[??[?X??[?X?[??]?[??\???X?[H Y?H\??Y[??????H\?Y??X?]?H\?[?[?H ?Y?K]Y[?H LY?H[??[XY? LY?H[??H?X]Y[?????\?]]?HZ[????Y??X?X?B????X?[H\??Y[??????HY??X?]?H[??[?\?]Y[?B??X]Y[?????X?Z[?\????X]Y?]H?\?Y]H???][???[??Y[???][X]?Y\??]\???[?\??]\?[??[??[????[]\?????X????X??Z[?[?ZY?Z[?H??[^\?????X?[H\??Y[?\?Y[??]?\?[?X[??????\?]]?HZ[???[YY?Y?\??\?[?\?\\???\??X?[???Y\?\????][ NNMJH[??\?Y?]YH??HY??X??[][??\??[??H??\?? Y?L?Y??????X?[H[???\\?Y]?]X?X??\??[\?LY??]??X?[??H?X]Y[??Z[?Y?\??\??X?[?[[?[?X[?X?[\?\?[?\??[?H?X?H?[??[??Z\?Y?YK??H?[???]Y[????\]YH?YK?H?[X\?HY??X?X?B?\?[Y]\??\??[Z[??[YY?Y?\??^?\??]?\???\??Y]????X?[HM?Y?[??Y??\??Y?Y?X?[?H?\\?[?????X?[B?Y?HY??X??LY??]??X??Y[YY??H]H]?[?Y??M?Y????X?[K?????][ NNM?H[?[??\??YH??\??YHY??X?????X?[H?\??\?[?[?H[?H?X?H?[??[??Z\?Y?X[??Z[??????Y?\?[?[?\??\?K?\??X[??\\?YH[?[?\?X?Y??X?X?H[??\?X?[]H?[??[]\??[\?[??X?[?????X?[H Y?Y?M?Y?[???Y?H?][?[?H LY?[??Y?H[?X?X??[??L?]Y[??][?\?]H??]?\?HZ[?????[???\??X?[?[[?[?[?[\X?Y?X[?X?[\?\?[?\???]Y[???X]Y?]???X?[H?[?[?H^\?Y[??YH?Y?Y?X?[?H?X]\?Z[??[YY??\?H??\???^?\?[??X?[?\?[?[??X?X???X?\Y[??\?Y??X?\X\?Y??H??H\[?[??]?]Y[??[?H???X?[H Y??[?[?HLY???\??X??[???Y?Y?X?[?H??\?Z[??[YY????\?[?]Y[??[?HY?\???Y?B???\??\?H?Y???????X?[H?\??[?\?]Y][??\?[??\?\????X]Y?]?H?Y?Y?X?[?H??\?[??Y[??H?Y?\??HY??X??[?[?[?HLY???Y?\?H[?[?\?X?Y??X?X?H?[??[]\??[\????X?[H]???\?[?H[? Y??\??\\?[??X?X??[?]??\?[?H[??Y??\?]X\?\?Y??X?]?H\?[??[]\??[\?[?[?H?Y??^?[?\???[][??X?YH?YH???\\?HH???\?]]?B?[?[?\?X?Y??X????[?\?]]?H[??]?[??\?\?X?][[?X??[?X???][H[????X?[K?[?\??YK?^H]Y[???][\X?Y\??[?\???[?\??[??\??X?[?[[?[?\?H?[??[H[??]Y[??YH??\???\ ?H? K??\ ?H? H[???\ ?H? K????\?X?Z]?Y?[?\?]]?[HY?\?X?][[? [??]?[?[?\??U?JK???\ ?[Y?X??[?X???][H ?[JH[???\Y????X?[B?U?K?????\?]]?HZ[?[?[??]KY][?[???[\[??[?[?\?X?????\?]]?[H[????\?]]?H??\X?][???\?H??\\?Y?[[????\?X^[][HZ[????\??\?H?X??Y???\?]]?B???\??\?H[?[??\?]Y[??^\?Y[??YY??]\?X?[????\?X??\?H??\\?X?H[[????\??\??YH???YY]?[?\?]]?H[??[]\??[\?X??[?X??[??]?[??\?\?X?][[?[????X?[HY??X?]?[HX?X\?YHZ[?????\?H]Y[???\?H?]\?YY?]H?YH???\?]]?HZ[??X[?Y?[Y[??Y?[Y[???[X\?][ NNM?H?YYYZ[??[YY?Y?\?\?\?X??^H[?[???\??\???[??[??Z\?Y?X[????X?[H?\??\??[XY??H?YH[??YY ??[X[H]Y[??Y?Y?M?HYX\???][?\?]H?[??\?X?H???\?]]?HZ[?????[??\?\?X??^K??Y?\??\??\?H???X?[H?\??]?[?\?[?U?[??X?[?[?H??H??Y?[?Y??[H?[XY??\??]?[?[?H??H? LY?]Y[????X?Z]?Y???X?[HY?YH?Y?Y?X?[?H??\?[YH??\????[YYX?][?[?X?X???X?\Y[??[?[?Y?]?HH?X]\???YX?[?[?Z[?[?[??]H[?H??\?[YH??]?]?[YH????\???H[??[XY?[?X?X??]Y[??????X?[H?\??[?\?]Y]????\?[??\?\????X]Y??]H??\?[??Y[??H?Y?\??HY??X??[??[XY??\?[??]?[??\????X?[H]H??H?Y??\??\\?[??X?X??[?]?X\?\?Y??X?]?H\?[??]?[??\??[XY? LY?[??[Y]?[??[?\?]B??[??\?X?H??\?\?X??^HZ[???\?\?[?K???X?[H?Y[YY?????\??H[?H?]??\?X?H?\?X?[]H??[H[??[XY???\??X[??][??X?YH?]?KY^H?X?KX?[??[??Z\?Y??YH[??X?HY??X?X?H[??Y?]H??[???X?[H\?X\?H?X]Y[??X?]H??X]X?K?[X??\??X]X?H?\???\\?Y?]X?X??[??X??[?X?H?YH???YY]H[?[?\?X?Y??X?X?H????X?[H\??\\?[??X?X??[??[Z[\??X??[?X?[?X?]H??X]X?K?[X??\??X]X?K?????[???][??X?Y[???\??\?X?[?X?X??X????Y?][\KY??H?YH?]\?Z[?HHY??X?X?H????X?[H[????\?]]?HZ[??]Y[???][?\?]H??]?\?HZ[?Y?\??[Z[?X??^K???\?H?[??Z\?Y??X?Z]?H???X?[H Y??Y?[??]?[??\?K]Y[?H LY?[??]?[??\?H?\???X?\?[Y?]\??X?X??H]Z\??\???\]Y\???[?[?\?XK?H?YH???YY]????X?[HY?[??]?[??\?H?\?\?Y??X?]?H\?]Y[?H LY??Y?H?BBBBBBBBBB????[X?\??L?H?X?X[\???[B??

The Specialist Forum Volume 13 No 11 November 2013 | Page 24