The Mirror - the Newsletter of CAPD ACDP June 2018 Mirror Merged PDF May 29, 2018 V3 | Page 15

IS HYPOPHOSPHATASIA (HPP)
IN YOUR PRACTICE?
99% of all patients with HPP
experience tooth loss (with the
root intact) before the age of 5 1
What is HPP?
A
 life-threatening genetic disorder 2
C
 aused by loss of function mutations in
the alkaline phosphatase gene ( ALPL ) 2
A
 LP enzyme deficiency disrupts
mineralization of bones and teeth, causing
numerous devastating consequences 2
LEARN MORE AT THE ALEXION-SPONSORED BREAKFAST SYMPOSIUM
SUNDAY, SEPTEMBER 16 TH , 2018 OR VISIT THE ALEXION BOOTH
REFERENCES:
1.  Whyte M, et al. Hypophosphatasia: Validation and expansion of the clinical nosology for children from 25 years experience with
173 pediatric patients. Bone . 2015;75:229-239.
2. Rockman-Greenberg C. Hypophosphotasia. Pediatr Endocrinol Rev . 2013;10:380-388.
Alexion is a registered trademark of Alexion Pharmaceuticals, Inc.
Copyright © 2018, Alexion Pharmaceuticals, Inc. All rights reserved.
CA/STQ-H/18/0029E