The Leaf THE LEAF Nov-Dec 2018 | Page 31

In doing so, the compound can have anti- anxiety and anti-depressant effects, while also helping reduce stress. 5. CBD is an Antiemetic Nausea and vomiting are really common symptoms. They can be the result of a specific condition, or can also be caused by treatments or medications such as chemotherapy. Both in humans and dogs, nausea and vomiting are serious symptoms, often leading to a decreased appetite, rapid weight loss, dehydration, fatigue, and more. There are plenty of antiemetic medications on the market, and some of the most common given to dogs and cats include acepromazine, chlorpromazine, aminobenzamide, and more. These drugs, while often effective in controlling nausea and vomiting, can cause a wide variety of side effects, including: • Hypotension • Strong sedation • Lowered seizure thresholds for animals with epilepsy • Excessive drooling • Lethargy • Lack of appetite • Diarrhea You can read more about antiemetic medications for animals and their adverse effects here. There is a strong body of evidence that shows that CBD is a successful antiemetic, controlling both nausea and vomiting while also stimulating appetite. Interestingly, it seems to do so by stimulating 5-HT1A receptors, the same receptor which can help reduce anxiety. By activating this receptor, CBD can significantly reduce feelings of nausea and also suppress the subsequent vomiting reflex. Research also suggests that prolonged stimulation of the CB1 cannabinoid receptor in the brain can also help reduce nausea and vomiting. In doing so, studies show that CBD can have powerful antiemetic effects. In fact, some studies suggest CBD is a better antiemetic than some modern medications. Best of all, CBD doesn’t cause any of the side effects of traditional antiemetic medications. 6. CBD May Slow Tumour Growth Cancer and malicious tumours are common in pets and, in many cases, prove to be fatal. Until now, there is no known cure for cancer, and treatment usually focuses on slowing the growth of a tumour while reducing pain and other symptoms. The most common treatment for cancer and tumours in pets is chemotherapy. Unfortunately, like with humans, chemotherapy can produce a wide variety of side effects, including: • Tiredness, fatigue, and lethargy • Loss of appetite • Vomiting • Diarrhea However, new research shows that cannabinoids like CBD can have unique anticancer effects, too. In fact, a growing body of research is beginning to explore just how cannabinoids can help slow the growth and spread of cancer and even reduce the size of tumours. For example, a 2011 study conducted at the Beth Israel Deaconess Medical Centre in Boston showed that CBD can cause programmed cell death and hence inhibit the growth of breast cancer. Another study, published by researchers from the University of Naples Federico II, Italy, also showed that CBD can help protect against colon cancer in rats by stopping the development, growth, and spread of malignant tumours. Research from Complutense University, Madrid, has also shown that CBD and other cannabinoids can enhance the effect of traditional chemotherapy. Researchers suggest it does so by increasing the rate by which cancer cells absorb chemotherapy agents, while simultaneously protecting healthy cells.