The Leaf THE LEAF July-August 2019 | Page 29

the cannabinoid THC (tetrahydrocannabinol), which the Food and Drug Administration allows for treatment of cancer and HIV- related symptoms like nausea and loss of appetite, which cannabis advocates say the raw plant material can treat without a corporate middleman. Insys said in its August filing it has no plans to resume those sales, though it is preparing a similar drug. Marijuana legalisation supporters say legal access to cannabis, which does not cause overdose deaths, could help combat overuse of medicine that serves as an on-ramp to potentially life-destroying addictions. Johns Hopkins University researchers concluded in 2014, after studying the effects of state medical marijuana laws through 2010, that "medical cannabis laws are associated with significantly lower state-level opioid overdose mortality rates." Currently, 25 states have laws allowing residents to use marijuana as medicine, though the plant remains a federally illegal Schedule I substance, which is defined as having no accepted medical value. The Obama administration has allowed states broad leeway to regulate sales of marijuana for recreational or medical use, despite federal prohibition, and major-party presidential candidates Hillary Clinton and Donald Trump have indicated they would pursue a similar approach. Arizona voters legalised medical marijuana in an initiative that won by about a 4,000-vote margin in 2010, and supporters of this year's legalisation initiative expect the ultimate vote to be close again, perhaps the closest of the five states – including Maine, Massachusetts, Nevada and California – that also will consider joining the four pioneering pot legalisation states and the nation's capital in November. Pro-legalisation campaign spokesman Barrett Marson says if the other side has any shame they will return Insys' donation, which is far and away the largest received by opponents to date. https://www.usnews.com/news/articles/2016- 09-08/fentanyl-maker-donates-big-to- campaign-opposing-pot-legalization