30 T. Rath et al.: J Extra Corpor Technol 2026, 58, 19 – 31
2. Borger MA, Feindel CM. Cerebral emboli during cardiopulmonary bypass: Effect of perfusionist interventions and aortic cannulas. J Extra Corpor Technol. 2002; 34:29 – 33.
3. Rodriguez RA, Williams KA, Babaev A, Rubens F, Nathan HJ. Effect of perfusionist technique on cerebral embolization during cardiopulmonary bypass. Perfusion. 2005; 20( 1): 3 – 10. https:// doi. org / 10.1191 / 0267659105pf778oa.
4. Rodriguez RA, Rubens F, Belway D, Nathan HJ. Residual air in the venous cannula increases cerebral embolization at the onset of cardiopulmonary bypass. Eur J Cardio-Thorac Surg. 2006; 29( 2): 175 – 180. https:// doi. org / 10.1016 / j. ejcts. 2005.11.006.
5. Taylor RL, Borger MA, Weisel RD, Fedorko L, Feindel CM. Cerebral microemboli during cardiopulmonary bypass: Increased emboli during perfusionist interventions. Ann Thorac Surg. 1999; 68( 1): 89 – 93. https:// doi. org / 10.1016 / S0003 – 4975( 99) 00475 – 0.
6. Chung EML. Transcranial doppler embolus detection: A primer. Ultrasound. 2006; 14( 4): 202 – 210. https:// doi. org / 10.1179 / 174313406X150122.
7. Jabur GN, Donnelly J, Merry AF, Mitchell SJ. A prospective observational study of emboli exposure in open versus closed chamber cardiac surgery. Perfusion. 2022; 37( 7): 715 – 721. https:// doi. org / 10.1177 / 02676591211023897.
8. Gupta P, Steiner LA. Role of transcranial doppler in cardiac surgery patients. Curr Anesthesiol Rep. 2021; 11( 4): 507 – 515. https:// doi. org / 10.1007 / s40140 – 021-00483 – 0.
9. Condello I, Lorusso R, Santarpino G, Fiore F, Nasso G, Speziale G. Clinical evaluation of micro-embolic activity with unexpected predisposing factors and performance of horizon AF PLUS during cardiopulmonary bypass. Membranes. 2022; 12( 5): 465. https:// doi. org / 10.3390 / membranes12050465.
10. Roosenhoff TPA, Stehouwer MC, De Vroege R, Butter RP, Van Boven WJ, Bruins P. Air removal efficiency of a venous bubble trap in a minimal extracorporeal circuit during coronary artery bypass grafting: Air removal efficiency of a venous bubble trap. Artificial Organs. 2010; 34( 12): 1092 – 1098. https:// doi. org / 10.1111 / j. 1525 – 1594.2009.00986. x.
11. Jabur GN, Sidhu K, Willcox TW, Mitchell SJ. Clinical evaluation of emboli removal by integrated versus non-integrated arterial filters in new generation oxygenators. Perfusion. 2016; 31( 5): 409 – 417. https:// doi. org / 10.1177 / 0267659115621614.
12. Lynch JE, Wells C, Akers T, et al. Monitoring microemboli during cardiopulmonary bypass with the EDACÒ quantifier. J Extra Corpor Technol. 2010;( 42): 212 – 218.
13. Willcox TW. Microemboli in our Bypass circuits: A contemporary audit. J Extra Corpor Technol. 2009; 41:31 – 37.
14. DeFoe GR, Dame NA, Farrell MS, Ross CS, Langner CW, Likosky DS. Embolic activity during in vivo cardiopulmonary bypass. J Extra Corpor Technol. 2014; 4( 46): 150 – 156.
15. Doganci S, Gunaydin S, Kocak OM, Yilmaz S, Demirkilic U. Impact of the intensity of microemboli on neurocognitive outcome following cardiopulmonary bypass. Perfusion. 2013; 28( 3): 256 – 262. https:// doi. org / 10.1177 / 0267659112470693.
16. Groom RC, Quinn RD, Lennon P, et al. Detection and elimination of microemboli related to cardiopulmonary bypass. Circ: Cardiovasc Qual Outcomes. 2009; 2( 3): 191 – 198. https:// doi. org / 10.1161 / CIRCOUTCOMES. 108.803163.
17. Dickinson TA, Riley JB, Crowley JC, Zabetakis PM. In vitro evaluation of the air separation ability of four cardiovascular manufacturer extracorporeal circuit designs. J Extra Corpor Technol. 2006:( 38): 206 – 213.
18. Jones TJ, Deal DD, Vernon JC, Blackburn N, Stump DA. How effective are cardiopulmonary bypass circuits at removing gaseous microemboli? J Extra Corpor Technol. 2002;( 34): 34 – 39.
19. Myers GJ. Preventing gaseous microemboli during blood sampling and drug administration: An in vitro investigation. J Extra Corpor Technol. 2007; 39:192 – 198.
20. Jones TJ, Deal DD, Vernon JC, Blackburn N, Stump DA. Does vacuum-assisted venous drainage increase gaseous microemboli during cardiopulmonary bypass? Ann Thorac Surg. 2002; 74( 6): 2132 – 2137. https:// doi. org / 10.1016 / S0003 – 4975( 02) 04081-X.
21. Nygaard K, Thiara A, Tronstad C, Ringdal M, Fiane A. VAVD vacuum may cause bubble transgression in membrane oxygenators. Perfusion. 2016; 31( 8): 648 – 652. https:// doi. org / 10.1177 / 0267659116651345.
22. Gallagher EG, Pearson DT. Ultrasonic identification of sources of gaseous microemboli during open heart surgery. Thorax. 1973; 28( 3): 295 – 305. https:// doi. org / 10.1136 / thx. 28.3.295.
23. Pearson DT, Watson BG, Waterhouse PS. An ultrasonic analysis of the comparative efficiency of various cardiotomy reservoirs and micropore blood filters. Thorax. 1978; 33( 3): 352 – 358. https:// doi. org / 10.1136 / thx. 33.3.352.
24. Myers GJ, Voorhees C, Haynes R, Eke B. Post-arterial filter gaseous microemboli activity of five integral cardiotomy reservoirs during venting: An in vitro study. J Extra Corpor Technol. 2009; 41:20 – 27.
25. Potger KC, Ccp MA. Microbubble Transmission during cardiotomy infusion of a hardshell venous reservoir with integrated cardiotomy versus a softshell venous reservoir with separated cardiotomy: an in vitro comparison. J Extra Corpor Technol. 2013; 45:77 – 85.
26. Mitchell S, Willcox T, McDougal C, Gorman D. Emboli generation by the Medtronic maxima hard shell adult venous reservoir in cardiopulmonary bypass circuits: a preliminary report. Perfusion. 1996; 11( 2): 145 – 155. https:// doi. org / 10.1177 / 026765919601100208.
27. Beckley PD, Shinko PD, Sites JP. A comparison of gaseous emboli release in five membrane oxygenators. Perfusion. 1997; 12( 2): 133 – 141. https:// doi. org / 10.1177 / 026765919701200208.
28. Herbst DP. The effects of pressure on gases in solution: possible insights to improve microbubble filtration for extracorporeal circulation. J Extra Corpor Technol. 2013; 45:94 – 106.
29. Herbst DP. Effects of purge-flow rate on microbubble capture in radial arterial-line filters. J Extra Corpor Technol. 2016; 48:105 – 112.
30. Clingan S, Schuldes M, Francis S, Hoerr H, Riley J. In vitro elimination of gaseous microemboli utilizing hypobaric oxygenation in the TerumoÒ FX15 oxygenator. Perfusion. 2016; 31( 7): 552 – 559. https:// doi. org / 10.1177 / 0267659116638148.
31. Johagen D, Appelblad M, Svenmarker S. Can the oxygenator screen filter reduce gaseous microemboli? J Extra Corpor Technol. 2014; 46:60 – 66.
32. Gisnarian CJ, Hedman A, Shann KG. An in-vitro study comparing the gme handling of two contemporary oxygenators. J Extra Corpor Technol. 2017; 49:262 – 272.
33. Liu S, Newland RF, Tully PJ, Psych M, Tuble SC, Baker RA. In vitro evaluation of gaseous microemboli handling of cardiopulmonary bypass circuits with and without integrated arterial line filters. J Extra Corpor Technol. 2011;( 43): 107 – 114.
34. Sathianathan S, Nasir R, Wang S, Kunselman AR, Ündar A. In vitro evaluation of Capiox FX05 and RX05 oxygenators in neonatal cardiopulmonary bypass circuits with varying venous