112 H. M. da Rocha Coutinho et al.: J Extra Corpor Technol 2025, 57, 105 – 112
5. Braile DPM. Shear stresses and turbulent eddies: the causes of mechanical hemolysis in a centrifugal blood pump, J Braz Soc Mech Sci Eng. 1998; 542 – 552.
6. Esper E, Rigsby HM, Devineni R, Kolff J. Elimination of arterial line clamping when coming off bypass with centrifugal pumps with the Centri-Safe TM valve in-line. J Extra Corpor Technol. 1995; 27( 2): 93 – 96.
7. Clark JB, Guan Yulong, McCoach R, Kunselman AR, Myers JL, Ündar A. An investigational study of minimum rotational pump speed to avoid retrograde flow in three centrifugal blood pumps in a pediatric extracorporeal life support model. Perfusion. 2011; 26( 3): 185 – 190.
8. Kurusz M. Perfusion safety: new initiatives and enduring principles. Perfusion, 2011; 26( Suppl 1): 6 – 14.
9. Vercaemst L. Hemolysis in cardiac surgery patients undergoing cardiopulmonary bypass: a review in search of a treatment algorithm. J Extra Corpor Technol. 2008; 40( 4): 257 – 267.
10. Bhirowo YP, Raksawardana YK, Setianto BY, et al. Hemolysis and cardiopulmonary bypass: meta-analysis and systematic review of contributing factors. J Cardiothorac Surg. 2023; 18( 1): 291.
11. American Society of ExtraCorporeal Technology A. Standards and guidelines for perfusion practice. J Extra Corpor Technol. 2013; 45( 3): 156 – 166.
12. Caneo LF, Matte G, Groom R, et al. The Brazilian Society for Cardiovascular Surgery( SBCCV) and Brazilian Society for Extracorporeal Circulation( SBCEC) standards and guidelines for perfusion practice. Braz J Cardiovasc Surg. 2019; 34( 2): 239 – 260.
13. Vargas Fonseca L. Flow-control valve arrangements and improvements. EUA patent US20160208940. 2016. Available at: https:// patents. google. com / patent / US20160208940A1.
14. Innovation ZM. Válvula unidirecional SafeCEC.
15. Cohen J. Quantitative methods in psychology: a power primer. Psychol Bull. 1992; 112( 1): 1155 – 1159.
16. Delacre M, Lakens D, Leys C. Why psychologists should by default use Welch’ s t-test instead of Student’ s t-test. Int Rev Soc Psychol. 2017; 30( 1): 92 – 101.
17. Cohen J. Statistical power analysis for the behavioral sciences. 2nd edn, NJ: Lawrence Erlbaum Associates; 1988.
18. Espirito Santo HA, Daniel F. Calcular e apresentar tamanhos do efeito em trabalhos científicos 2: guia para reportar a força das relações. Rev Port Inv Comp Soc. 2017; 3( 1): 53 – 64.
19. The Jamovi Project. 2023. Available at: https:// www. jamovi. org. Cited September 15, 2023.
20. Högman CF, Hedlund K, Sahlestrom Y. Red cell preservation in protein-poor media. III. Protection against in vitro hemolysis. Vox Sang. 1981; 41( 5): 274 – 281.
21. Baskurt OK, Meiselman HJ. Erythrocyte aggregation: basic aspects and clinical importance. Clin Hemorheol Microcirc. 2013; 53( 1 – 2): 23 – 37.
22. Silva GVLPFLSGSAOMEA. Hemólise em circulação extracorpórea: correlação com tempo e outros fatores. Rev Bras Cir Cardiovasc. 2009; 24( 2): 180 – 187.
23. Oliveira GMM, Brant LCC, Polanczyk CA, et al. Estatística cardiovascular – Brasil 2021. Arq Bras Cardiol. 2022; 118( 1): 115 – 373.
24. Kolff J, McClurken JB, Alpern JB. Beware centrifugal pumps: not a one-way street, but a potentially dangerous“ siphon”. Ann Thorac Surg. 1990; 50( 3): 512.
25. Vieira Junior FU, Antunes N, Vieira RW, Madalena L, Álvares P, Costa ET. Hemólise na circulação extracorpórea: correlação com tempo e procedimentos realizados. Braz J Cardiovasc Surg. 2012; 27( 4): 535 – 541.
Cite this article as: da Rocha Coutinho HM, de Souza Aguiar Coutinho JH, Torres JH, Casanova RM, Kikuta G & Reis EE. Clinical evaluation of SafeCEC Ò one-way valve in hemolysis during CPB: Pilot study. J Extra Corpor Technol 2025, 57, 105 – 112. https:// doi. org / 10.1051 / ject / 2025010.