J Extra Corpor Technol 2025, 57, 96 – 104 Ó The Author( s), published by EDP Sciences, 2025 https:// doi. org / 10.1051 / ject / 2025008
Available online at: ject. edpsciences. org
ORIGINAL ARTICLE
The utility of sTREM-1 and presepsin to predict infection in pediatric patients receiving mechanical circulatory support
Robert Murray( MD) 1,*, Jianli Bi( MD, PhD) 2, 3, Robin Alexander( MS) 4, Md Rejuan Haque( PhD) 5, Brian Beckman( BSN) 2, 3, Ruth Seabrook( MD) 1, 6, W. Joshua Frazier( MD) 1, 7, and Andrew R. Yates( MD) 1, 7, 8
1 Nationwide Children’ s Hospital, 700 Children’ s Drive, Columbus, OH 43205, USA 2 Nationwide Children’ s Hospital, Molecular Core for Cardiovascular Research, 700 Children’ s Drive, Columbus, OH 43205, USA 3 Nationwide Children’ s Hospital, Heart Center, 700 Children’ s Drive, Columbus, OH 43205, USA 4 Biostatistics Resource at Nationwide Children’ s Hospital, 700 Children’ s Drive, Columbus, OH 43205, USA 5 Department of Biomedical Informatics, Center for Biostatistics at The Ohio State University, 1800 Children’ s Drive, Columbus, OH
43210, USA 6 The Ohio State University College of Medicine, Department of Pediatrics, Division of Neonatology, 1645 Neil Ave, Columbus, OH 43210, USA 7 The Ohio State University College of Medicine, Department of Pediatrics, Section of Critical Care Medicine, 1645 Neil Ave, Columbus, OH 43210, USA 8 The Ohio State University College of Medicine, Department of Pediatrics, Section of Cardiology, 1645 Neil Ave, Columbus, OH 43210, USA Received 26 November 2024, Accepted 24 March 2025
Abstract – Background: It is difficult to clinically detect a new infection in patients with Mechanical Circulatory Support( MCS; including veno-arterial and veno-veno extracorporeal membrane oxygenation, and ventricular assist devices). The prompt, accurate identification of new infection utilizing plasma biomarkers could prompt earlier initiation of antimicrobial agents and may improve outcomes. Methods: We utilized ELISA to evaluate novel biomarkers, soluble Triggering Receptor Expressed on Myeloid cells( sTREM-1) and Presepsin, as well as existing biomarkers( C-Reactive Protein( CRP) and Procalcitonin) before MCS, daily for the first week of MCS and for the 72 h in advance of the development of a new infection for patients prospectively enrolled in a biobank and who developed a culture positive infection. Results: Serial samples from 18 patients were analyzed. On average post-cannulation Presepsin and sTREM-1 values were not significantly different, however they have higher baseline values than reported in other patient populations. On average during periods of infection, Presepsin was 41 % lower( 51,462 – 30,188 pg / mL)( P = 0.001) and procalcitonin was 51 % lower( 0.77 – 0.38 ng / mL)( P < 0.001) compared to non-infected periods. Neither CRP or sTREM-1 were significantly different between infected and un-infected periods. Conclusion: Presepsin and Procalcitonin decreased in advance of the development of a new infection in the MCS patient population, a direction of change different than expected. These findings highlight the importance of biomarker studies specifically performed in the MCS patient population, and the potential lack of translatability of biomarkers in other patient populations to the MCS patient population.
Key words: ECMO, Mechanical circulatory support, sTREM-1, Presepsin, Infection.
Abbreviations
CRP C-Reactive Protein ECPR cannulation to MCS during the process of active cardiopulmonary resuscitation MCS Mechanical Circulatory Support sTREM-1 soluble Triggering Receptor Expressed on Myeloid cells VAD Ventricular Assist Device
Introduction
Mechanical Circulatory Support( MCS), including: venoarterial and veno-veno extracorporeal membrane oxygenation, and ventricular assist devices, is utilized to provide support for the heart, lungs or both for the most critically ill children in the intensive care unit [ 1 ]. Survival to hospital discharge in those who received MCS ranges from 41 to 74 % with neonatal respiratory indications having the best outcome and ECPR
* Corresponding author: Robert. murray @ nationwidechildrens. org
This is an Open Access article distributed under the terms of the Creative Commons Attribution License( https:// creativecommons. org / licenses / by / 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.