J Extra Corpor Technol 2024 , 56 , 191 – 202 Ó The Author ( s ), published by EDP Sciences , 2024 https :// doi . org / 10.1051 / ject / 2024023
Available online at : ject . edpsciences . org
REVIEW ARTICLE
Enhancing lung transplantation with ECMO : a comprehensive review of mechanisms , outcomes , and future considerations
Salman Pervaiz Butt ( MBA , MSc , MPHYS , ACCP , FCCP , CES-A ) 1 ,* , Vivek Kakar ( MD ) 2 , Salman Abdulaziz ( MD ) 3 , Nabeel Razzaq ( AACP , MSc ) 4 , Yasir Saleem ( MSc ) 5 , Arun Kumar ( MD ) 6 , Fazil Ashiq ( MD ) 7 , Praveen Ghisulal ( MD ) 8 , Aaron Thrush ( DPT ) 9 , Sadaf Malik ( APRN-C ) 10 , Mairead Griffin ( BSN , PgDip ) 11 , Mahanoor Amir ( DPT ) 12 , Umar Khan ( MD ) 13 , Ashal Salim ( BSN ) 14 , Zaid Zoumot ( MD ) 15 , Izanee Mydin ( MD ) 16 , Yazan Aljabery ( MD ) 17 , Gopal Bhatnagar ( MD ) 18 , Yusuf Bayrak ( MD ) 19 , Andres Obeso ( MD ) 19 , and Usman Ahmed ( MD ) 20
1 Interim Manager Perfusion Services , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 2 Director ECMO Program , Critical Care Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 3 Consultant of Cardiovascular Critical Care , Co-Chair of ECMO Task Force , Department of Health , United Arab Emirates 4 Clinical Perfusionist , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 5 Perfusionist , All India Institute of Medical Sciences , Sri Aurobindo Marg , Ansari Nagar , New Delhi 110029 , India 6 Department Chair , Cardiothoracic Aesthesia , Anesthesiology Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi ,
United Arab Emirates 7 Anesthesiology Physician , Anesthesiology Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 8 Critical Care Associate Staff Physician , Critical Care Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 9 Physical Therapist , Critical Care Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 10 Physician Assistant , Critical Care Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 11 Nurse Manager , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 12 Physical Therapist , Shalimar Medical and Dental College , Shalimar Link Road , Lahore , Punjab 54000 , Pakistan 13 Critical Care Consultant , Critical Care Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 14 Charge Nurse , Critical Care Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 15 Department Chair Pulmonology , Pulmonology Institute , PO BOX 112412 , Abu Dhabi , United Arab Emirates 16 Consultant Transplant Surgeon , The Newcastle Upon Tyne Hospitals NHS Foundation Trust , Freeman Hospital , Freeman Road ,
High Heaton , NE7 7DN , UK 17 Associate Staff Physician , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 18 Institute Chair , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 19 Thoracic Physician , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi , United Arab Emirates 20 Departmental Chair Thoracic Surgery , Heart Vascular and Thoracic Institute , Cleveland Clinic , PO BOX 112412 , Abu Dhabi ,
United Arab Emirates Received 7 June 2024 , Accepted 25 July 2024
Abstract – Background : Lung transplantation ( LTx ) is a critical intervention for patients with end-stage lung disease . However , challenges such as donor organ scarcity and post-transplant complications significantly affect its success . Recent advancements in Extracorporeal Membrane Oxygenation ( ECMO ) have shown promise in improving the outcomes and expanding eligibility for LTx . Methods : A comprehensive literature review was conducted , focusing on studies that explore the use of ECMO in lung transplantation . A thorough search of relevant studies on ECMO and LTx was conducted using multiple scholarly databases and relevant keywords , resulting in 73 studies that met the inclusion criteria . Sources included peer-reviewed journals and clinical trial results , with emphasis on articles captured recent advancements in ECMO technology and techniques . Results : ECMO has been crucial in supporting patients before , during , and after LTx . It serves as a bridge to transplantation by maintaining pulmonary and circulatory stability in critically ill patients awaiting donor organs . ECMO also aids in the evaluation of marginal donor lungs and supports patients through acute post-transplant complications . Recent technological advancements have improved the
* Corresponding author : buttsab9 @ hotmail . com
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