The Journal of ExtraCorporeal Technology No 56-3 | Page 35

110 K . Kashiwa et al .: J Extra Corpor Technol 2024 , 56 , 108 – 113
Table 1 . Patients ’ characteristics , laboratory data , drug , intraoperative data .
Increased group ( n = 10 )
Non-increased group ( n = 17 )
p value
Height ( cm )
160.1 ( 155.3 – 170.6 )
160.2 ( 155.2 – 165.3 )
0.451
Weight ( kg )
49.5 ± 15.4
48.0 ± 14.9
0.817
BSA ( m 2 )
1.48 ± 0.25
1.44 ± 0.27
0.688
Preoperative Hct (%)
38.3 ± 4.9
41.2 ± 6.4
0.234
Preoperative Plt ( 10 3 / lL )
319 ± 97
274 ± 125
0.338
Preoperative Fbg ( mg / dL )
464.4 ± 136.9
430.3 ± 108.0
0.480
Preoperative WBC ( 10 3 / lL )
9.2 ( 8.0 – 10.8 )
7.9 ( 7.2 – 9.4 )
0.138
Preoperative CRP ( mg / dL )
1.28 ( 0.88 – 1.77 )
0.49 ( 0.13 – 1.87 )
0.108
Preoperative Albumin ( g / dL )
3.8 ( 3.5 – 4.2 )
4.2 ( 3.7 – 4.4 )
0.243
Preoperative APTT ( sec )
28.5 ± 5.1
27.2 ± 3.2
0.450
Preoperative use of immunosuppressants (%)
70.0
58.8
0.692
Number of double lung transplantation
9
10
0.204
ECMO duration ( min )
314.2 ± 48.4
257.9 ± 70.5
0.035
Time from starting ECMO to UFH infusion rate increase ( min )
161.3 ± 72.7
0
< 0.001
Table 2 . Lung diseases .
Increased group
Non-increased group
Bronchiectasis
2 ( 20.0 %)
2 ( 11.8 %)
Chronic GVHD after HSCT
2 ( 20.0 %)
2 ( 11.8 %)
Idiopathic interstitial pneumonia
2 ( 20.0 %)
5 ( 29.4 %)
Collagen disease interstitial pneumonia
3 ( 30.0 %)
1 ( 5.9 %)
Others
1 ( 10.0 %)
7 ( 41.1 %)
Real numbers (%). GVHD : graft versus host disease , HSCT : hematopoietic stem cell transplantation .
Table 3 . Changes in ACT , infusion rate of UFH .
Time point
ACT ( sec )
Infusion rate of UFH ( units / kg / h )
Increased group
Non-increased
p value
Increased
Non-increased
p value
group
group
group
Immediately after starting ECMO
211.0 ( 193.5 – 265.0 )
253.5 ( 221.5 – 270.5 )
0.223
6.77 ± 0.94
7.80 ± 1.65
0.082
1 – 2 h after starting ECMO
179.0 ( 166.5 – 188.5 )
224.0 ( 193.0 – 242.0 )
0.006
6.88 ± 0.89
7.46 ± 2.13
0.423
After reperfusion of the first lung
163.0 ( 151.5 – 179.5 )
227.0 ( 164.5 – 249.5 )
0.023
8.25 ± 1.73
7.29 ± 2.13
0.242
After reperfusion of the second lung *
150.7 ± 17.1
197.5 ± 51.8
0.041
11.72 ± 2.95
7.66 ± 2.81
0.009
* Only in bilateral lung transplantation .
Table 4 . Changes in platelet count , WBC count .
Platelet count ( 10 3 / lL )
WBC count ( 10 3 / lL )
Increased group
Non-increased group
p value
Increased group
Non-increased group
p value
Before starting ECMO
186 ± 53
157 ± 69
0.261
8.4 ( 6.2 – 10.7 )
6.8 ( 5.2 – 8.5 )
0.183
Immediately after starting ECMO
162 ± 50
140 ± 58
0.342
8.4 ± 2.9
7.0 ± 2.2
0.176
1 – 2 h after starting ECMO
160 ± 42
129 ± 53
0.136
12.6 ± 3.3
9.5 ± 4.0
0.046
After reperfusion of the first lung
148 ± 55
138 ± 55
0.664
10.6 ( 7.9 – 15.0 )
8.4 ( 5.8 – 11.5 )
0.182
After reperfusion of the second lung *
124 ± 65
84 ± 32
0.139
10.3 ± 3.9
9.2 ± 5.1
0.621
After ECMO ended
88 ( 82 – 142 )
111 ( 74 – 120 )
0.986
10.6 ± 4.1
8.7 ± 4.2
0.264
* Only in bilateral lung transplantation .
other times , the average WBC count tended to be higher in the increased group all through the surgery ( Table 4 ). Regarding blood product transfusion , a statistically significant difference was observed only in the amount of fresh frozen plasma
( FFP ) after reperfusion of one lung to the end of ECMO ( Table 5 ). The percentage of neutrophils , eosinophils , and basophils at the WBC fraction immediately after surgery was 92.1 ( 89.9 – 94.7 ), 0.1 ( 0 – 0.1 ), and 0.1 ( 0.1 – 0.1 )%, respectively .