The anti-inflammatory mechanisms of CBD
CBD can interact with a wide variety of a molecular targets in our body. Its anti-inflammatory
effect is mediated by interacting with different receptors (cannabinoid, adenosine, GPR55),
ion channels (TRPV1) and enzymes (lipoxygenase, cyclooxygenase-2). CBD interacts directly
with specific immune cells, supressing the production of proinflammatory compounds and
increasing the levels of anti-inflammatory compounds. These effects, in conjunction with its
other therapeutic effects, make CBD a very effective compound in inflammatory processes.
Other anti-inflammatory phytocannabinoids
CBD is not the only cannabis constituent that has anti-inflammatory effects. Other
phytocannabinoids, such as THC, cannabinol, their acidic precursors, tetrahydrocannabinolic
acid and cannabidiolic acid, as well as terpenes (D-limonene, β-caryophyllene, β-pinene)
have all shown anti-inflammatory activity. An interesting observation is that when these
compounds are taken together, as whole plant extracts, they potentiate the therapeutic
effects of the single compounds, making them more efficacious and needing lower doses to
achieve the same effects.
The verdict
Studies, as well as consumer experiences, are showing the beneficial therapeutic effects CBD
can have. As inflammation is present in our daily lives, it is a good idea to add CBD and other
anti-inflammatory compounds to our daily regime, as a preventive measure or as a more
focused therapy.
About the author
Gregor Zorn is medical cannabis consultant, educator and researcher. His main area of interest
is practical implementation of phytocannabinoid therapies for specific medical conditions.
He is an international speaker specialised in teaching medical professionals, patients and
students about all aspects of cannabinoids and their important role in health and disease.
He is the co-founder of the European Cannabinoid Therapy Association (ECTA) and one of
the teachers at the first European Medicinal Cannabis post-graduate educational course,
at Padua University Medical School in Italy. He is a teacher at the Masterclass Medicinal
Cannabis, a member of the International Association for Cannabinoid Medicines (IACM) and
a founding member, author and scientific advisor to Zbudimo.se.