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C URCUMIN AND M EMORY : A LZHEIMER ’ S AND D EMENTIA
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Institute of Neurological and Communicative Disorders and
Stroke–Alzheimer Disease and Related Disorders Association.
They were given either a placebo or one or four grams of
BCM-95 ® Curcumin. There were few side effects and, interest ingly,
the most side effects occurred in the placebo group.
Researchers commented on the resulting increased levels of
beta-amyloid in the bloodstream as indicative that the beta-amyloid
plaque formations in their brains were dissolving and the blood-
stream was carrying them away for waste disposal.
In addition, BCM-95 ® has been selected for study in a ground-
breaking, exciting, year-long Australian clinical study searching for
ways to prevent or delay the expected declines of Alzheimer’s dis-
ease, being conducted by renowned Australian researcher Ralph
Martins, Ph.D., who directed the study on beta-amyloid plaque
mentioned previously on page 30.
As head of the Sir James McCusker Unit for Alzheimer’s Dis-
ease Research for over 20 years, Director of the Centre of Excel-
lence for Alzheimer’s Disease Research and Care, Director and
Inaugural Chair for Ageing and Alzheimer’s Disease at Edith
Cowan University in Perth, Australia, Dr. Martins is working to
develop an early diagnostic blood test in order to effectively prevent
and/or treat this devastating degenerative brain disease.
In addition, Dr. Martins and his team are working to substan-
tiate their theory that the presence of curcumin in the retina of the
eye, when it is bound to the beta-amyloid plaque, may help doctors
diagnose Alzheimer’s in its earliest stages and perhaps reverse the
disease process with more curcumin. I am very excited about Dr.
Martins’ work and look forward to results that will change the face
of Alzheimer’s disease, prevention, diagnosis and treatment in the
not-too-distant future.
Curcumin studies in animal models of Alzheimer’s disease have
demonstrated that it can play a significant role in the destruction
of beta-amyloid plaque. It is also a powerful antioxidant, with an
ORAC value of 1.5 million per 100 grams, as determined by the
United States Department of Agriculture (USDA). Other studies