SALIVARY AND SERUM CORTISOL IN PATIENTS WITH PERIODONTAL DISEASE AND ORAL
LICHEN PLANUS
Daniela Miricescu
Teaching Assistant, PhD
Department of Biochemistry, Faculty of Dental Medicine “Carol Davila” University of Medicine
and Pharmacy Bucharest, Romania
CV
Her PhD, focused on the study oxidative stress as a new pathological
biochemical mechanism in oral diseases, using saliva as a new
diagnostic fluid in oral diseases.
In the spring of 2011, during an exchange program, worked
at Università Politecnica delle Marche, Italia, under the direct
supervision of Maurizio Battino, PhD, DSc, MS, MD (Hon), focusing
on the biochemical mechanisms of oxidative stress and antioxidants.
Her current research interests are, oxidative stress, oral stem cells
properties, nanoparticles, and their possible interaction with the oral
stem cells and generation of oxidative stress.
Questions
Regarding this study:
q a. The general aim of our study was to investigate the levels of cortisol in stimulated whole saliva
q b. 50 patients were included in our study
q c. Psychological stress may influence the evolution and progression of periodontal disease and
oral lichen planus
q d. Salivary cortisol was measured using RT-PCR method
Regarding the patients included in our study:
q a.
q b.
q c.
q d.
1.0-2.0 of non-stimulated whole saliva and 5 ml of blood were collected from patients
Optical density was read at 550 nm
40 patients with OLP with the age between 61–68 years
15 males and 5 females formed the patients with periodontal disease
Regarding the salivary levels:
q a.
q b.
q c.
q d.
All the results were statistically decreased
The cortisol at patients with periodontal disease was 10.1±1.03
The cortisol at patients with oral lichen planus was 9.08±1.056
The cortisol at patients with periodontal disease was 3.17±0.63
Regarding the serum levels:
q a.
q b.
q c.
q d.
Levels for cortisol were not statistically significant
The cortisol at patients with periodontal disease was 3.17±0.63
The cortisol at patients with oral lichen planus was 9.25±1.97
The cortisol at patients with oral lichen planus was 9.08±1.056
STOMA.EDUJ (2015) 2 (1)
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