A COMPREHENSIVE REVIEW OF SYSTEMIC FACTORS ASSOCIATED WITH PERI-IMPLANT DISEASES
alpha( TNF-α) and interleukin 1-beta( IL-1β) release on titanium stimulation were significantly higher among patients with implant failure. The results showed that IL-1β / TNF-α release and number of risk genotypes were significantly associated with implant failure. 71 Vaz et al. 72 examined IL-1 gene clusters in 155 patients with 100 successful implants and 55 unsuccessful implants. The authors concluded that successful implants were associated with a negative genetic test and that unsuccessful implants were associated with a positive genetic test. 72 Casado and colleagues reported that the IL-6 genotype was 1.53 times more likely to convey peri-implant disease if the individuals had the GC
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Conflict of interest and financial disclosure The author reports no conflict of interest and there was no external source of funding for the present study.
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