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In terms of innovation, consider continuous flow processing and low footprint manufacturing( Figure 5).
Continuous manufacturing opens up a lot of new processing windows. A few examples include the use of photochemistry reactors to build up molecules rapidly or the use of high pressure, high temperature chemistry, and even supercritical chemistry. Dangerous conversion reactions can be done effectively and safely by continuously limiting the concentration of these dangerous reagents or their intermediates.
Another tool to drive sustainability is performing gas reactions in flow. Hydrogen and oxygen are the simplest and most atom-effective molecules for hydrogen reductions and oxidations.
Ajinomoto Sustainable Solutions is investigating hydrogenation inflow using static mixers. If that is combined with high pressure, this also opens up opportunities to use base methods. If aiming for solvent free chemistry, then mechanochemistry comes into the picture, which is an earlystage technology.
To achieve our 2030 goals, though, we are developing a few long shots, including mechanochemistry. In this case, solid-to-solid conversions are targeted by working without solvents
or with minimal solvents, which is then classified as paste chemistry.
Collaborate with partners from Day 1
Of late, drug developers are increasingly interested in sustainable process development. Ultimately, the effort needs to be phase-appropriate as the path from Phase I to market is long. Phase II is the critical point at which a sustainable, relatively commercial-ready process should be established. At Phase III, final adjustments are made to optimise loss, i. e., solvent recycling and simplified unit operations.
Rather than a silver bullet, manufacturers need a diverse toolbox to build more sustainable processes. We are striving to think innovatively with a range of strategies, including continuous manufacturing, efficient synthetic routes, and simplified process stages with limited work-up. ●
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About Ajinomoto Sustainable Solutions
Ajinomoto Sustainable Solutions has over 50 years of CDMO experience, with a strong track record in“ deliver-to-promise” performance. Backed by powerhouse Ajinomoto Omnichem, we are here not only to help you lower your Scope 3 emissions but to make you more competitive by turning existing routes into lowerimpact, cost-efficient alternatives. We focus on the development and scaling up of processes from lab to multi-ton quantities with a specialization in continuous flow, biocatalysis and photo flow chemistry.
We see our clients as partners, working together to improve the wellbeing of humankind and our planet. We work with companies in various sectors, such as cosmetics, fragrances, food and feed, agroscience companies. They trust upon us to solve complex problems and create innovative products that are greener and much more cost efficient. It’ s what we do on a daily basis.
We are Ajinomoto Sustainable Solutions, your CDMO partner for a competitive advantage.
Figure 5- Ajinomoto Sustainable Solutions’ strategic innovation areas
Development, scale up and manufacturing |
Sustainable chemistry |
Biocatalysis |
Continuous flow |
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From lab to multi ton commercial scale:
Deep expertise in PAT
QbD implementation
Effective continuous improvement programmes
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Selective chemistries Renewable sources Precious group metal recovery Water based chemistry |
Different classes of enzymes at commercial scale
Immobilised enzymes
In house process engineering
Access to Ajinomoto’ s enzyme production network
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Continuous flow manufacturing for liquids, slurries and gas liquid systems
In house capabilities: photochemistry, high pressure and temperature slurry reactions, slow and heterogeneous chemistry
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MAR / APR 2026 SPECCHEMONLINE. COM
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