ADVERTORIAL
Revolutionising peptide synthesis : Senn Chemicals at the forefront of innovation
In this ever-evolving world , peptides have established their efficacy as versatile compounds , with applications ranging from skincare formulations to life-saving therapeutic drugs , offering targeted therapeutic solutions with high specificity and low toxicity .
Over the past decades , peptide manufacturing has undergone significant transformations , too . As demand for peptides continues to rise , the selection of the optimal technology has in itself evolved into an art .
Depending on the peptide length and the quantities needed , the choice of the right technology exerts a significant impact on cost-effectiveness , scalability and sustainability ( Figure 1 ). This article sets out to highlight the advantages and disadvantages of different technologies available .
SPPS : Quick turnaround for initial development
Solid phase peptide synthesis ( SPPS ) excels in terms of speed , which is crucial in fast-paced industries like cosmetics and pharmaceuticals . It accelerates early development of peptide-based drug candidates , facilitating swift translation from lab research to clinical trials .
However , in the long-term SPPS use may lead to significant downstream processing expenses . Another challenge arises from the trend towards longer peptide lengths , resulting in decreased yields when utilising SPPS . The global shortage of SPPS manufacturing capacities presents an additional challenge , leading to extended lead times .
LPPS : Economies of scale & environmental considerations
Given these limitations , liquid phase peptide synthesis ( LPPS ) has reemerged as an economic and sustainable manufacturing technology . Pioneered by Senn Chemicals , LPPS offers unparalleled advantages , as it is a cost-competitive method for production at scale , typically with a higher net present value ( NPV ) than SPPS .
LPPS involves fewer synthetic steps and reagents , leading to reduced production costs and increased profit margins . Higher product purity is achieved with fewer purification steps , leading to reduced operational expenses and waste .
Large-scale commercial production with LPPS reduces production times , enabling faster turnover and revenue generation . Overall , these factors contribute to LPPS ’ s potential for greater financial returns and a higher NPV .
With a two to five times reduction in process mass intensity ( PMI ), LPPS offers significant cost reductions compared to SPPS . PMI represents the ratio of overall material input to the resulting material output , serving as a metric for process efficiency .
The lower PMI in LPPS indicates that materials are utilised more efficiently , resulting in cost reductions with an improved sustainability . Reduced solvent consumption is an especially important factor here , aligning with the growing environmental consciousness in the market .
Lately , LPPS has also regained attention in the cosmetic sector for its contributions to sustainability initiatives for CMR and PFAS-free products .
Figure 1 - Technology overview of peptide synthesis
HPPS : An alternative combination
Hybrid phase peptide synthesis ( HPPS ) offers a synergistic approach , combining small-scale peptide fragments generated through SPPS with solution-based LPPS to costeffectively synthesise larger peptides .
Senn Chemicals : Your Trusted Partner in Peptide Synthesis
Senn Chemicals , an FDA-inspected CDMO based in Switzerland , holds a rich legacy in cGMP custom LPPS and HPPS peptide manufacturing . With over six decades of experience , Senn has established itself as a trusted partner for cosmetic and pharmaceutical companies , offering comprehensive services that span the entire value chain , from amino acid building blocks to the final peptides .
Senn ’ s commitment as a leading CDMO is emphasised through its fundamental values of prioritising customers , operational excellence and ensuring sustainability . By choosing Senn , clients around the globe not only gain access to unparalleled expertise in LPPS , but also benefit from significant cost-savings and a strong commitment to sustainability . Partnering with Senn provides an opportunity to experience the innovation , efficiency and quality that sets a benchmark in the dynamic world of peptides . ●
MAR / APR 2024 SPECCHEMONLINE . COM
31