A new solution for oral and dental care
Stefan Fellner of Premium Organic presents some new results for Alpine Heilmoor Extract in oral care applications
The oral cavity is home to some 500 species of bacteria . The synergy and interaction between these microorganisms help the human body to fight against the invasion of undesirable stimulation from outside . An oral microbial dysbiosis , caused by abnormal proliferation of certain pathogenic bacteria , can lead to oral inflammation , and the development of periodontal and systemic diseases . Two common oral infections which affect the tissues that surround and support the teeth are :
• Periodontitis , a chronic inflammatory disease , causing tooth loss and deterioration of the gingiva , alveolar bone and periodontal ligaments
• Gingivitis , an inflammatory condition of the gingival tissue , characterised by gingival redness ,
Figure 2- Dose-dependent reduction of senescent cells by AHE
Figure 1 - Immediate & long-term effect of 5 % AHE on P . gingivalis in vitro
swelling and bleeding , and a prerequisite for the development of periodontal disease . The prevalence of periodontal disease has been reported to range from 20 % to 50 % around the world and is considered a major health problem . 1 A key pathogen , Porphyromonas gingivalis , is strongly implicated in the pathogenesis of periodontitis . 2 This bacterium is a gram-negative , rod-shaped , obligate anaerobe . 3 It infects periodontal tissues as a secondary infection through interactions with commensal streptococci . 4 In addition , P . gingivalis induces impairment of oral epithelial barrier functions , which raise susceptibility to microbial infections , leading to local tissue inflammation responsible for periodontitis and systemic diseases . 5 A recent study shows that it induces premature senescence , a cellular process defined as irreversible cell cycle arrest which contributes to ageing and age-related diseases . 6 Antibiotics are used to target anaerobic bacteria , especially P . gingivalis . However , some strains show resistance levels which require the development of alternative and natural treatments
34 SPECIALITY CHEMICALS MAGAZINE ESTABLISHED 1981