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Catalyst selection & scale-up of your process
Catalysts and ligands provide a gateway to new reactions. Finding the right catalyst or ligand can streamline chemical development and manufacturing, improve yield and reduce both costs and environmental concerns.
How do you determine and implement the best possible catalytic process for your target compound? High-throughput screening( HTS), combined with a screening library of catalysts, allows rapid evaluation of reagents, catalysts, and conditions. With HTS, you can quickly determine which catalyst or ligand gives you the best yield, the fastest transformation, the mildest conditions or the cleanest reaction. This requires specialised resources, technology, and expertise. What if you don’ t have that in-house?
A robust partnership between Sinocompound and InCatT bridges the gap between catalyst lead finding and commercialisation. InCatT specialises in catalyst screening and development. Combined with Sinocompound’ s scale-up expertise, this collaboration significantly reduces development time and time to market.
HTS technology for pressurised and non-pressurised reactions, in addition to a screening library of catalysts, allows InCatT to perform rapid leadfinding for catalysts and ligands – up to 96 catalysts / day. Does your process require asymmetric hydrogenation? Hydroformylation? Cross-coupling? High enantioselectivity? InCatT’ s large libraries of homogeneous, heterogeneous and supramolecular catalysts are analysed to find the ideal conditions to produce your product.
Once the ideal catalyst or ligand is found, reaction condition optimisation is performed using the AMTECH platform. With DoE strategies, reaction kinetics and gas uptake curves, InCatT identifies the ideal reaction parameters to create your product.
When you have found the ideal catalyst or ligand, it may not be commercially available in the quantities required for scale-up, and this can delay, or even entirely prevent, manufacturing. In this case, you have several options for how to proceed:
• Find a different catalyst, through additional screening. This requires more development time and costs. The new catalyst may require you to compromise yield, price or reaction conditions in favour of availability
• Find a new synthetic route that removes the catalyst requirement. This also requires more development time and costs. Often, no alternative route is available. If there is an alternative route, it may require higher temperatures, harsher conditions, or more toxic reagents
• Make the required catalyst inhouse. This adds more steps to your process and may require additional equipment or expertise
• Work with a specialist like Sinocompound to make your ideal catalyst
Specialists have the facilities and expertise to produce your catalyst at scale and at the speed required for your timeline. Sinocompound performs on-demand catalyst development and scale-up and has their own library of catalysts and ligands.
If you need an uncommon catalyst or a novel ligand, Sinocompound has the manufacturing sites and R & D teams to take your catalytic system from gram to kilo scale in just 16
weeks( depending on the length of the synthetic route). In partnership with InCatT, Sinocompound can determine early in the screening process which catalysts and ligands are commercially viable for scale-up to the quantities that you need for your target compound.
In addition, Sinocompound is ISOcertified, giving you the security of knowing that your catalyst will be made with the quality needed for any chemical industry, from agricultural chemicals to fine chemicals to pharmaceutical manufacturing.
The ideal catalyst will give you a robust and reproducible process while reducing costs and waste. If you want flexibility, quality and speed, look to the development partnership of Sinocompound and InCatT. Their combined expertise provides shorter development times and reduces your target compound’ s time to market. You don’ t need to settle for an inferior catalyst, and you don’ t need to spend the time producing the catalyst yourself. Let a specialised catalyst development company like Sinocompound deliver the catalyst, ligands and peace of mind to drive your product to the next level. ●
J j
SINOCOMPOUND sales @ sinocompound. com en. sinocompound. com
JAN / FEB 2026 SPECCHEMONLINE. COM
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