Speciality Chemicals Magazine JAN / FEB 2021 | Page 52

Steven McIntyre , peptide process development manager at Almac , looks at a key technology trend in peptide development

Improved peptide analytical technologies

& the impact on process development

Steven McIntyre , peptide process development manager at Almac , looks at a key technology trend in peptide development

In recent years there has been a

huge increase in the development of technologies for the analysis of peptides . In particular , the use of U ( H ) PLC columns and systems is routine in all peptide analytical laboratories . Most manufacturers of these columns offer technology in which the column chemistry is specifically designed to increase the separation of peptide impurities from the main component . Furthermore , there is
Figure 1 – U ( H ) PLC analysis of peptide using first generation analytical method ( a ) & developed analytical method ( b )
( a )
( b )
52 SPECIALITY CHEMICALS MAGAZINE ESTABLISHED 1981