Continuous flow applied to peptide synthesis -
Next generation of synthesisers
Peptide manufacturers can bring solid-phase peptide synthesis to a whole new level by following Big Pharma ’ s interest in flow chemistry , says Dr Manuel Nuño of Vapourtec
Continuous flow chemistry
has been a powerful tool for discovery chemistry and process development in the fine chemical and pharmaceutical industries since the early 2000s . Flow chemistry provides much more accurate control of temperature , residence time and diffusion in chemical reaction , allowing for a deeper understanding of kinetics . If scientists can automate the screening of reactions at small scale , they can learn about the reaction and quickly optimise conditions to implement it rapidly at pilot scale , minimising the risk of failure .
The early adoption of flow chemistry in these industries gave the pioneer companies a key technological advantage over competitors who adopted the technique later . Now , as manufacturers of flow chemistry systems , we at Vapourtec are seeing the same trend with the peptide synthesis community .
The key – automation
Solid-phase peptide synthesis ( SPPS ) is the heterogeneous chemical strategy to synthesise peptides bound to a solid support that wass
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Figure 1 – Vapourtec VBFR & reactor controller
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