Sevenoaks Catalyst Magazine - Planet Earth Issue 2 - Summer term 2020 | Page 25

So, I don’t think that these tests are very informative about the types of relations between people, beyond first, second, or third cousins, because everyone is, roughly, as related to each other at that point. The notion that these types of products can tell you things about your ancestry and your sense of selfidentity, I think, is really short. They’re commercial products, and the market will determine how successful they are, but I think that as scientists, we are obliged to explain what the product is. SG: In your most recent publication, you mention that the utility of customer genetictesting can play a part in white supremacy discourse. Does the notion of ancestral purity have any scientific grounding? Dr Rutherford: There’s been a normalisation of what we might call biological essentialism, the idea that your character, your identity, is innate, and engrained in your DNA. I’m a geneticist, and I don’t think that’s true. Our genetic relatedness to our ancestors is relatively weak. That doesn’t mean that cultural identity is not important. Much of the argument in the book and the lecture, is that cultural identity is important, but when you try to wed it to genetic identity, that is where we have a scientific problem. When white supremacists rely on the notion of ancestral purity in order to prop up their hateful ideologies, they can’t use genetics to do that, because genetics doesn’t say that, it doesn’t say that there is racial purity, it says quite the opposite. The concept of racial purity is just non-scientific. That is where these types of products, I think, are unhelpful in these conversations. People should know what they’re purchasing, and understand what it is that these products can actually say, and then people are free to make their own decisions. Caveat emptor. SG: In your book, ‘Creation’, you refer to bacterial reproduction as a major challenge associated with determining the origin of our species. Bacteria do not only vertically pass on their genetic material, but also horizontally transfer their genes. Recent human feeding studies have displayed the potential for genetically modified soybean to transfer the gene for antibiotic resistance to natural bacteria of our small intestine. Do you think that the hitherto lack of viable solutions for antibiotic resistance stems from such multifaceted methods of bacterial reproduction? Dr Rutherford: Yes, quite right. I think that antibiotic resistance is one of the great crises that we face at the moment. It’s showing limited signs of improving. There are multiple reasons for this, but the basic scientific reason is that horizontal gene transfer is something that bacteria do very efficiently. Couple that with overuse of antibiotics, and you’ll see that we have effectively driven the artificial selection of antibiotic resistance. Add that to the fact that there are no new classes of antibiotics that have been discovered for ten, fifteen years (although new antibiotics have); the financial incentive for developing antibiotic chemicals and compounds, into becoming drugs, is very low. It’s very expensive to develop drugs; it’s a billion dollars to get from chemical to market. So, there isn’t a lot of investment into developing new drugs. There are new techniques, we reported on one last week: artificial intelligence using machine learning to identify already existing compounds that have antibiotic potential. They still need to be turned into drugs, it’s a multi-stage process. You know, identifying a compound that is antibiotic is not the same as manufacturing a drug.