Facilitate tissue repair
®
REGENFAST promotes the microenvironment and enhances cell vitality to support
1 more efficient repair .
REGENFAST ®
> Sterile viscoelastic gel based on Polynucleotides ( PN ) and Hyaluronic Acid ( HA ) > Of natural origin > Completely resorbable
Hyaluronic Acid
Tissue Hydration : > Fibroblast survival > In combination with PN , can potently promote wound healing 2
Polynucleotides
Trophic Stimulus : > Fibroblast stimulus > Matrix production > Collagen increase
PN are linear biopolymers , which are composed of several nucleotide monomers with covalent bonds in a chain . Each strand of a polynucleotide consists of an alternate sugar and a phosphate group . 3
Mannitol
Protection : > Reduces HA degradation by 34 % 4 > Antioxidant
PN appeared to be effective at stimulating the growth of primary gingival fibroblasts and , in combination with HA , can potently promote
2 wound healing .
Geistlich Select – Regenfast ® BIO501005 Regenfast , 0,3ml
Control HA
PN
“ Microphotography of healing wounds in the control ( A , D ), HA ( B , E ) and PN ( C , F ) after Sirius Red staining for the collagen at transmitted ( A , B , C ) or polarized light ( D , E , F ) 2 weeks after surgery . 5 |
A |
B |
C |
( A , D ): The defect is still devoid of collagen fibers . 5 ( B , E ): The collagen fibers only partially occupy the healing tissue area . 5 ( C , F ): The wounds are almost completely healed , and collagen fibers appear mature and well organized incomparison to control and HA Magnification = 4x .” 5
D
control = culture medium
100μm 100μm 100μm
E F
100μm 100μm
100μm
2
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