46TH
ANNUAL
CONGRESS
OF
THE
SAEVA
SKUKUZA
16-‐20
FEBRUARY
2014
119
Metronidazole
15-20
mg/kg q
8h orally
20 –25
mg/kg q8
h rectally
Bacteriocidal
Wide distribution
Concentration dependant
Anaerobic bacteria
Good tissue penetration
Protozoa
Active in abscesses
Cross blood brain
barrier
25mg/kg
q 12 h
orally
Absorbed after rectal
administration (serum
concentrations lower than oral)
Anorexia (decreased with rectal
admin)
Neurological side effects with
high doses
Tetrogenic
35 mg/kg
Q 12 H
per
rectum
References:
1.
2.
3.
Bowen M. Antimicrobial Stewardship: Time for Change. Equine Veterinary Journal 2013 (Vol
45) 127 - 129
Papich M.G., Davis J.L. Antimicrobial Therapy in Equine Infectious Diseases. Ed D.C. Sellon,
M.T. Long. 2007. Ch 71 pg 549 - 555
Wilson W.D. Rational Selection of Antimicrobials for Use in Horses. Proceedings of the
Annual Convention of the AAEP 2001. Vol 47 pg 75 – 93
119