118
46TH
ANNUAL
CONGRESS
OF
THE
SAEVA
SKUKUZA
16-‐20
FEBRUARY
2014
Excellent tissue
penetration
Tetracyclines
Bacteriostatic
Broad spectrum
Gram +ve, gram –ve,
anaerobes
Crosses blood brain
barrier
Effective against ehrlichia,
richetsia and anaplasma
Active against
intracellular bacteria
Active in abscesses and
acidic environments
Flexural deformities
Anti-inflammtory and antimetalloproteinase effects
(laminitis, osteoarthritis,
pulmonary fibrosis, melting
ulcers)
Acute tubular necrosis
Severe muscle reaction if IM
Hypotension and collapse with
rapid IV injection
Binds to calcium causing teeth
and bone discoloration
Oxytet
racyclin
e
5 mg/kg
IV q 12h
Doxycy
clines
10mg/kg
q 12h
orally
Good gram +ve
(not IV –
sudden
death)
Minocy
cline
4mg/kg q
12h
orally
Chloramphenicol
50 mg/kg
q 6h
orally
Bacteriostatic (cidal at high
conc)
Wide distribution
Broad spectrum
Good intracellular
penetration
Gram +ve, gram –ve,
anaerobes
Active