116
46TH
ANNUAL
CONGRESS
OF
THE
SAEVA
SKUKUZA
16-‐20
FEBRUARY
2014
Amikac
in
10
mg/kg IV
q 24 h
Amikacin has a wider spectrum
of activity than gentamicin.
Less nephrototoxic than
gentamicin
Foals: 20
- 25
mg/kg q
24 h
Potentiated - sulphonamides
Strepto
micin
Extensive resistance
30 mg/kg
(of drug
combinat
ion) q 12
h orally
Bactericidal
15 – 24
mg/kg q
8 – 12 h
IV
(slowly)
Poor anaerobic
High lipid solubility, wide
distribution and good
tissue penetration.
Broad spectrum
Gram +ve and gram –ve
Crosses blood brain
barrier.
Decreased activiy in pus
/ purulent fluids. (TMS
interferes with synthesis
of folic acid from PABA,
with sulphonamide
competively inhibiting
PABA and purulent
tissues are rich in PABA)
(TMP has
short half
life in
horses
therefore
BID
dosing
necessar
y)
Reaction to intravenous
trimethorpim/ sulfadiazine esp
when given rapidly (collapse and
death)
Do not give IV TMS with
detomodine (dysrhythmias and
death)
Do not give concurrently with
procaine penicillin
Neutropenia with prolonged
use (folate synthesis
suppressed)
Absorption from GIT reduced
with feeding.
Sulfadiazine is better than
sulfamethoxazole
Bacterial resistance common
IMHA
116