114
Anti
bioti
c
Dose
Penicillin
Antibioti
c class
46TH
ANNUAL
CONGRESS
OF
THE
SAEVA
SKUKUZA
16-‐20
FEBRUARY
2014
Spectrum of
activity
Distribution
Notes and adverse
reactions
Bactericidal
Low lipid solubility, poor
tissue penetration
IMHA
Time dependant
Activity reduced in acid
environments i.e.
abscesses and tissue
necrosis
Penicilli
nG
Sodium
/
potassi
um pen
Gram +ve
Gram +ve anaerobes
Inactivated by B-lactamase
enzymes from many
Staphylococcus spp, gram
negative enteric bacteria, and
bacteroides
10000 –
40000
iu/kg q 46 h IV or
IM
Short serum elimination half-life
and no post-antibiotic effect,
frequent dosing or CRI.
Give 30 min prior to colic
Surgery and after 80 min if still
in surgery.
Procain
e
penicilli
n
22 000
IU/kg q
12 – 24 h
IM
Procaine reaction.
Concentration of free procaine
in bottles increased following
exposure to heat.
Horses develop muscle
soreness / myositis after
prolonged use
Benzat
hine
penicilli
n
Not
recomm
ended
because
of low
plasma
concentr
ations
Ampicil
lin and
amoxici
llin
Broader spectrum of activity
against gram –ve.
Le 727F