Gregory Webster , Megan J . Puckelwartz , Lorenzo L . Pesce , et al . Genomic Autopsy of Sudden Deaths in Young Individuals . JAMA Cardiol . Published online August 11 , 2021 . doi : 10.1001 / jamacardio . 2021.2789
Question : Can genomic analysis improve clinical care for families after a sudden death in young individuals ? Findings : In this cohort study of 103 decedents from a national collaboration of medical examiners , pathogenic / likely pathogenic variants in arrhythmia or cardiomyopathy genes were identified in 13 %. In multivariate analysis , rare variants in cardiac genes ( pathogenic / likely pathogenic / uncertain significance ) were associated with younger age at death . Meaning : Genomic autopsy found clinically actionable cardiac variants in 13 % of sudden deaths in young individuals , but a more sophisticated model of multiple gene effects or oligogenic model may be required to optimize clinical care for families .
Amanda E . Paluch , Kelley Pettee Gabriel , Janet E . Fulton et al . Steps per Day and All-Cause Mortality in Middle-aged Adults in the Coronary Artery Risk Development in Young Adults Study . JAMA Netw Open . 2021 ; 4 ( 9 ): e2124516 . doi : 10.1001 / jamanetworkopen . 2021.24516
Question : Are step volume or intensity associated with premature mortality among middle-aged Black and White women and men ? Findings : In this cohort study of 2110 adults with a mean follow-up of 10.8 years , participants taking at least 7000 steps / d , compared with those taking fewer than 7000 steps / d , had a 50 % to 70 % lower risk of mortality . There was no association of step intensity with mortality regardless of adjustment for step volume . Meaning : This cohort study found that higher daily step volume was associated with a lower risk of premature all-cause mortality among Black and White middle-aged women and men .
Liam D . A . Paget ; Gustaaf Reurink , Robert-Jan de Vos et al . Effect of Platelet-Rich Plasma Injections vs Placebo on Ankle Symptoms and Function in Patients with Ankle Osteoarthritis . A Randomized Clinical Trial . JAMA . 2021 ; 326 ( 16 ): 1595-1605 .
Question : Do intra-articular platelet-rich plasma injections improve ankle symptoms and function in patients with ankle osteoarthritis ? Findings : In this randomized clinical trial that included 100 patients , treatment with 2 intra-articular platelet-rich plasma injections vs placebo injections with saline resulted in a mean change in the American Orthopaedic Foot and Ankle Society score ( range , 0-100 ; higher scores indicate less pain and better function ) of 10 vs 11 points over 26 weeks ; the between-group difference was not statistically significant . Meaning : These findings do not support the use of platelet-rich plasma injections for patients with ankle osteoarthritis .
Revista de Medicina Desportiva informa janeiro 2022 ยท 19