Research Platforms' Performance Reports BRIMS 2015-2017 | Page 7

Microtome
Micropipette Puller
Key Techniques and Services
Histology
• Basic histology
• Immunohisto/cytochemistry
• Immunofluorescence
• In situ hybridisation
• Multiple labeling
• Cryosectioning
• Vibratome
Imaging
• Digital slide scanner
• Confocal microscope
• Multiphoton microscope
Drug Discovery Platform
Platform Leader: Associate Professor Tomoko Soga
The Drug Discovery platform encompasses expertise in the first steps of the drug discovery process (target identification
and validation, hit finding and lead optimization), contributing significantly towards lead time and cost reduction involved
in the process from initial project proposals to the start of their clinical phase. It also endeavours to kindle innovation in
biological research by providing access to cutting edge drug screening and evaluate resources with a particular emphasis
on developing novel drugs to improve human and animal health, and biotechnological improvement of aquaculture for
food security.
iPS Cell Facility
In 2016, induced pluripotent stem cells (iPSC) facility was created by the Drug Discovery Platform at BRIMS. The facility
is located at Building 3 Level 3 which consists of: 1) two procedure rooms equipped with biosafety cabinets, CO 2 / O 2
incubator, refrigerated centrifuge machine, dual fluorescence cell counter and a nucleofector unit; 2) an imaging room
equipped with Nikon TE2000 with a high resolution cool CCD camera (DXM-1200C) and control software (ACT-1 and
NIS-Elements D). Observation, image capturing and image data analysis of bright field and fluorescence samples for iPSC
culture can be done using the imaging software (NIS elements D3.0).
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