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Table of Contents:
1. The Case for Innovation 6 2. Clinical and Commercial Landscape 10 3. Assessment of Pipeline Product Innovation 25 4. Type 2 Diabetes Mellitus Signaling Network, Disease Causation and Innovation Alignment
48 5. First-in-Class Target and Pipeline Program Evaluation 54 6. Strategic Consolidations 67
List of Tables:
Table 1: Type 2 Diabetes Mellitus, Global, Related Indications of T2DM First-in-Class Products, 2016 49 Table 2: Type 2 Diabetes Mellitus, Global, Pipeline Programs Targeting Insulin Receptor Substrate 1, 2016 55 Table 3: Type 2 Diabetes Mellitus, Global, Key Features of Insulin Receptor Substrate 1, 2016 55 Table 4: Type 2 Diabetes Mellitus, Global, Pipeline Programs Targeting Insulin Receptor Substrate 2, 2016 55 Table 5: Type 2 Diabetes Mellitus, Global, Key Features of Insulin Receptor Substrate 2, 2016 55 Table 6: Type 2 Diabetes Mellitus, Global, Pipeline Programs Targeting G-Protein Coupled Receptor Kinase 5, 2016 56 Table 7: Type 2 Diabetes Mellitus, Global, Key Features of G-Protein Coupled Receptor Kinase 5, 2016 57 Table 8: Type 2 Diabetes Mellitus, Global, Pipeline Programs Targeting Type 2 Angiotensin II Receptor, 2016 58 Table 9: Type 2 Diabetes Mellitus, Global, Key Features of Type 2 Angiotensin II Receptor, 2016 58 Table 10: Type 2 Diabetes Mellitus, Global Pipeline Programs Targeting Islet Amyloid Polypeptide, 2016 59 Table 11: Type 2 Diabetes Mellitus, Global, Key Features of Islet Amyloid Polypeptide, 2016 59 Table 12: Type 2 Diabetes Mellitus, Global, Pipeline Programs Targeting Nacht LRR and PYD Domains Containing Protein 3, 2016 60 Table 13: Type 2 Diabetes Mellitus, Global, Key Features of Nacht LRR and PYD Domains Containing Protein 3, 2016 61
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