Research Analysis Reports Frontier Pharma Type-2 Diabetes Research Report

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Frontier Pharma-Type 2 Diabetes Mellitus Market Research Report 2020

Frontier Pharma : Type 2 Diabetes Mellitus - GPCRs and Protein Kinases Dominate Pipeline , with Most Promising First-in-Class Targets Demonstrating Potential Disease-Modifying Effects
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Summary :
‣ Type 2 diabetes mellitus ( T2DM ) is a chronic , progressive and serious metabolic disorder characterized by hyperglycemia ( high blood glucose levels ) and associated with numerous complications and co-morbidities , including cardiovascular , renal and neurodegenerative diseases .
‣ Global prevalence of the disease has risen rapidly in the past several decades , primarily as a result of rising obesity , a major risk factor for T2DM . This has resulted in a large and competitive market landscape , with a number of drugs competing with one another for different market segments , across multiple lines of therapy .
‣ The emergence over the past decade of glucagon-like peptide-1 ( GLP-1 ) receptor agonists , dipeptidyl peptidase 4 ( DPP-4 ) inhibitors and sodium-glucose cotransporter 2 ( SGLT-2 ) inhibitors has intensified competition . These new drug classes have been highly commercially successful and are now well established within the treatment algorithm .
‣ In spite of these developments , there are still significant unmet needs for T2DM , and the rationale for investment in first-in-class innovation remains strong . First-in-class products account for a considerable proportion of the large T2DM pipeline , with a diverse range of first-in-class targets identified .
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