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Cystic Fibrosis - Heat Map and Analysis Market Research Report
Cystic fibrosis ( CF ) is a progressive genetic condition and is the result of a patient inheriting a faulty cystic fibroses transmembrane conductance regulator ( CFTR ) gene from both parents . The defective CFTR genes produce faulty CFTR proteins on the body ’ s epithelial cells , and result in the buildup of a thick and sticky mucus in the lungs and pancreas . Historically therapeutic options have focused heavily on treating the symptoms , but despite being clinically and commercially successful have failed to address the faulty CFTR proteins that cause the disease . This unmet need has led to the development of CFTR modulators .
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The treatment algorithm patients receive is likely to consist of an antimicrobial , a mucolytic agent , pancreatic enzymes and possibly a CFTR modulator . This tabular heatmap framework , designed to provide an easily digestible summary of these clinical characteristics , provides detailed information on all late-stage clinical trial results for products in the CF market and Phase III or Preregistration stages of the pipeline . These are split along drug class lines , and are therefore reflective of the treatment algorithm .
All safety and efficacy endpoints reported in these trials are displayed . In addition , key study characteristics such as the size , composition and patient segment of the study population are provided . These results are presented in a visually accessible , color-coded manner in order to maximize ease of use .
The accompanying text provides a detailed analysis of the clinical benchmarks set by the current market landscape , and the anticipated changes to these benchmarks , and to the treatment algorithm , as a result of the late-stage pipeline .
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