Replication-Competent Lentivirus Testing
Lentiviral vectors have demonstrated great potential as gene therapy
vectors mediating efficient in vitro and in vivo gene delivery and long-
term transgene expression in both dividing and nondividing cells. They
have the advantages of a large cloning capacity, the lack of a
requirement for viral gene expression, and the capacity to integrate into
the target cell genome for stable transduction. In addition, they are
highly efficient for in vivo gene delivery in a broad range of hosts cells,
such as neurons, endothelial cells, hepatocytes, and hematopoietic stem
cells.