68 H. Murat et al.: Radioprotection 2025, 60( 1), 65 – 75
Risk coefficients: Absorbed dose:
BEIR VII Phase II data( Based on studies of health effect in atomic bomb)
Biokinetic data from ICRP 128
Tabulation of b coefficients for organs in Table 4
Administered activity( MBq) data for all 40 patients.
Estimation of LAR for specific organ, age at exposure( Y) and gender
Organ absorbed dose( DT)( IDAC-Dose 2.1)
Organ absorbed dose were converted to organ cancer risk.
Average cancer risks were estimated for a certain age at exposure and gender for whole-body 18 F-FDG PET / CT.
Fig. 1. A schematic diagram of the fundamental elements for predicting LAR cancer incidence.
In this paper, we have polished the text by using AI Stork ' s Writing Assistant( https:// www. storkapp. me / writeassistant /) and significantly improved the coherence of the writing. Notably, the use of this AI tool did not influence the originality of the manuscript and its scientific facts.
3 Results
3.1 PET / CT dosimetry
The
mean absorbed doses( D T) and their standard deviations across different organs were quantified for whole-body 18 F-FDG PET imaging using internal dose assessment software, IDAC-Dose 2.1. Table 2 provides a detailed breakdown of the results. The analysis revealed that the bladder received the highest absorbed dose, while the thyroid received the lowest among the organs studied for both genders.
In this study, E was calculated separately for PET and CT in accordance with the ICRP recommendation. The distribution of the administered activity, A and E for PET, as well as
CTDI vol, DLP, and E for CT, were analyzed to gain a better understanding of the distribution of radiation dose received by all 40 patients. Table 3 provides a summary of patient doses for whole body 18 F-FDG PET / CT examinations. It is apparent from this table that the mean E for PET was 6.85 ± 1.82 mSv, while for CT it was substantially higher at 13.24 ± 6.10 mSv, resulting in a combined mean total E of 20.09 ± 7.85 mSv for PET / CT examinations.
3.2 Organ cancer risk based on LAR of cancer incidence
Table
4 outlines b coefficients for various organs, obtained by fitting data from BEIR VII phase II report as indicated in equation( 5), and used to calculate the LAR. These coefficients allow for a detailed assessment of the cancer risks associated with specific organ dose and age at exposure from PET / CT examinations.
The absorbed doses and corresponding LAR for various organs in men and women during 18 F-FDG PET / CT