Pushin' On: UAB Spinal Cord Injury Model System Digital Newsletter Volume 36 | Number 2
Pushin’ ON
VOL 36 | NUM 2
2018
UAB Spinal Cord Injury Model System Digital Newsletter
Headline News
The University of Alabama at
Birmingham Spinal Cord Injury
Model System (UAB-SCIMS) provides
Pushin’ On twice annually as an
informational resource for people
with spinal cord injury (SCI).
UAB-SCIMS Program Director:
Amie B McLain, MD
Pushin’ On Editor: Phil Klebine, MA
529 Spain Rehabilitation Center
1717 6th Avenue South
Birmingham, AL 35233-7330
Phone: 205-934-3283
TDD: 205-934-4642
Fax: 205-975-4691
WWW.UAB.EDU/SCI
[email protected]
/UABSCIMS
/UABSCIMS
/UABSCIMS
The contents of this
publication were developed
under a grant from the
National Institute on Disability, Independent
Living, and Rehabilitation Research (NIDILRR
grant number 90SI5019). NIDILRR is a Center
within the Administration for Community
Living (ACL), Department of Health and
Human Services (HHS). The contents of this
publication do not necessarily represent the
policy of NIDILRR, ACL, HHS, and you should
not assume endorsement by the Federal
Government.
©2018 University of Alabama Board of Trustees. The
University of Alabama at Birmingham provides equal
opportunity in education and employment.
In previous issues of Pushin’ On, we’ve highlighted the amazing
progress by researchers at University of Louisville in Kentucky. They
have helped a handful of people paralyzed after spinal cord injury to
move and walk again under limited conditions.
In a recent publication in the New England Journal of Medicine, the
team added new insights into the ongoing research. The published
results were that two of the four participants (both AIS grade B) were
able to walk over ground with a common walker after intensive physical
training with electrical stimulation of the lower spinal cord. The other
two (AIS grade A) achieved some components of independent stepping
on the treadmill with body-weight support but not over-ground walking.
None of the four participants could do these actions in trials when the
stimulator was off.
Motor and sensory scores for three participants did not change from
the scores before implantation. In one participant, however, the motor
score improved from 23 to 24 and the sum of the sensory scores from
83 to 86.
Here’s a video with the patients and researchers.
The University of Louisville in Kentucky has sparked a new line of
research. Two other publications also highlight results in electrical spinal
cord stimulation.
A resent publication in Nature Medicine highlighted results by
researchers at Mayo Clinic and UCLA. A man had a spinal cord
neurostimulator implanted below the injury (T6 AIS grade A). After rehab,
the man is able to stand alone and make independent steps while
holding onto the walker when the device was turned on. He walked 111
yards, took 331 steps, and spent 16 minutes walking with assistance.
Here’s a video with the patient and researchers.
A resent publication in Nature Neuroscience highlights results by
researchers at École polytechnique fédérale de Lausanne (EPFL) in
Switzerland using a new electrical stimulation method. This team was
able to mimic in real time how the brain naturally activates the spinal
cord. This was done with a large electrode array that was able to
stimulate various parts of the spinal cord and control different groups of
muscles at the same time the brain was attempting the same actions.
It seems the timing and where the neurostimulation happens play a big
part in making muscles move as desired.
After months of training, they got three people with spinal cord injuries
to walk and to even move their legs without any electrical stimulation at
all, although crutches or walkers were used. They also reported at least
one of the participants has even been able to take multiple steps without
holding onto anything at all.
But, what is even more important, it looks like nerves actually grow
and make new connections when the timing matches what the brain
wants to do.
Here’s a video with the patients and researchers.