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PROTAC ( Proteolysis Targeting chimera ) platform of ARVINAS pharmaceutical
7 . Targeting Xtandi and Zytiga Non Responder and Resistant population
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‣ Causes of resistance -Emerging mechanisms of Resistance to Xtandi / Zytiga
‣ How do the Mechanism of resistance to the Zytiga and Xtandi differ and do some of them overlap ?
‣ Can AR-V7 splice biomarker be used to determine whether Xtandi and Zytiga will work ??
‣ What other studies are looking at different ways to overcome resistance ??
‣ Who will win the race for AR-V7 variant mCRPC ??
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