‣ Current market size of prostate cancer 4 . Xtandi
‣ Xtandi – current uptake o Xtandi current US prescription trend and its uptake
• Xtandi Price issue o Xtandi uptake in Europe o Xtandi uptake in Japan
‣ Xtandi- additional opportunities in Prostate Cancer o Xtandi in nmCRPC- PROSPER study
• Urology opportunity / Xtandi as a preferred urology drug
• Xtandi Market Potential in nmCRPC � �
Xtandi Price Issue in nmCRPC Xtandi duration of therapy in nmCRPC
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o Xtandi – additional clinical trials in Prostate Cancer
• Xtandi in M1 Hormone Sensitive patients
• Xtandi in Mo Hormone Sensitive patients
• Xtandi other ongoing clinical studies o Xtandi with Pfizer early stage Prostate cancer Pipeline drug
‣ Xtandi in Other Indications o Xtandi Potential in Breast Cancer o Xtandi in Hepatocellular Carcinoma
‣ Xtandi in combination with New pipeline drugs